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CYP2A13 CYP2A13 CYP2E1 CYP2E1 CYP2D6 CYP2D6 CYP3A4 CYP3A4 HSD3B1 HSD3B1 HSD3B2 HSD3B2 HSD11B1 HSD11B1 AKR1D1 AKR1D1 PPARG PPARG CYP11B2 CYP11B2 CYP11B1 CYP11B1
"HSD11B1" - hydroxysteroid in Homo sapiens
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HSD11B1hydroxysteroid (11-beta) dehydrogenase 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity) (292 aa)    
Predicted Functional Partners:
AKR1D1
aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase); Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7- alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4- cholesten-3-one can also act as substrates (326 aa)
 score_image         score_image score_image   0.959
HSD3B1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17- alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandr [...] (373 aa)
       score_image   score_image score_image   0.955
HSD3B2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids (372 aa)
       score_image   score_image score_image   0.948
CYP11B1
cytochrome P450, family 11, subfamily B, polypeptide 1; Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB (503 aa)
           score_image score_image   0.937
PPARG
peroxisome proliferator-activated receptor gamma (505 aa)
           score_image score_image   0.932
CYP11B2
cytochrome P450, family 11, subfamily B, polypeptide 2; Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone (503 aa)
           score_image score_image   0.929
CYP3A4
cytochrome P450, family 3, subfamily A, polypeptide 4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1’-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide (503 aa)
           score_image score_image   0.919
CYP2D6
cytochrome P450, family 2, subfamily D, polypeptide 6; Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants (497 aa)
         score_image score_image score_image   0.916
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13; Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N- dimethylaniline, 2’-methoxyacetophenone, N- nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity (494 aa)
         score_image score_image score_image   0.913
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms (493 aa)
         score_image score_image score_image   0.913
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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