EPB41L4A protein (Homo sapiens) - STRING network view

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EPB41L4A

erythrocyte membrane protein band 4.1 like 4A (686 aa)

Predicted Functional Partners:

TAAR1

0.813

CCDC134

0.659

FBXO18

0.620

TXNL4B

0.619

RAPGEF3

0.577

NBL1

0.546

ZMYND12

0.501

SRPK2

0.461

SRPK1

0.461

ARHGAP21

0.459

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARHGAP21	CCDC134	ENSP00000379709	ENSP00000255784	Rho GTPase activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions	coiled-coil domain containing 134	0.514
ARHGAP21	EPB41L4A	ENSP00000379709	ENSP00000261486	Rho GTPase activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions	erythrocyte membrane protein band 4.1 like 4A	0.459
ARHGAP21	FBXO18	ENSP00000379709	ENSP00000369335	Rho GTPase activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions	F-box protein, helicase, 18	0.490
ARHGAP21	RAPGEF3	ENSP00000379709	ENSP00000373864	Rho GTPase activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions	Rap guanine nucleotide exchange factor (GEF) 3; Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis	0.452
CCDC134	ARHGAP21	ENSP00000255784	ENSP00000379709	coiled-coil domain containing 134	Rho GTPase activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions	0.514
CCDC134	EPB41L4A	ENSP00000255784	ENSP00000261486	coiled-coil domain containing 134	erythrocyte membrane protein band 4.1 like 4A	0.659
CCDC134	FBXO18	ENSP00000255784	ENSP00000369335	coiled-coil domain containing 134	F-box protein, helicase, 18	0.664
CCDC134	RAPGEF3	ENSP00000255784	ENSP00000373864	coiled-coil domain containing 134	Rap guanine nucleotide exchange factor (GEF) 3; Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis	0.619
CCDC134	TXNL4B	ENSP00000255784	ENSP00000268483	coiled-coil domain containing 134	thioredoxin-like 4B; Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition	0.636
EPB41L4A	ARHGAP21	ENSP00000261486	ENSP00000379709	erythrocyte membrane protein band 4.1 like 4A	Rho GTPase activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions	0.459
EPB41L4A	CCDC134	ENSP00000261486	ENSP00000255784	erythrocyte membrane protein band 4.1 like 4A	coiled-coil domain containing 134	0.659
EPB41L4A	FBXO18	ENSP00000261486	ENSP00000369335	erythrocyte membrane protein band 4.1 like 4A	F-box protein, helicase, 18	0.620
EPB41L4A	NBL1	ENSP00000261486	ENSP00000289749	erythrocyte membrane protein band 4.1 like 4A	neuroblastoma, suppression of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process	0.546
EPB41L4A	RAPGEF3	ENSP00000261486	ENSP00000373864	erythrocyte membrane protein band 4.1 like 4A	Rap guanine nucleotide exchange factor (GEF) 3; Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis	0.577
EPB41L4A	SRPK1	ENSP00000261486	ENSP00000362931	erythrocyte membrane protein band 4.1 like 4A	SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...]	0.461
EPB41L4A	SRPK2	ENSP00000261486	ENSP00000377262	erythrocyte membrane protein band 4.1 like 4A	SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...]	0.461
EPB41L4A	TAAR1	ENSP00000261486	ENSP00000275216	erythrocyte membrane protein band 4.1 like 4A	trace amine associated receptor 1; Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained s [...]	0.813
EPB41L4A	TXNL4B	ENSP00000261486	ENSP00000268483	erythrocyte membrane protein band 4.1 like 4A	thioredoxin-like 4B; Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition	0.619
EPB41L4A	ZMYND12	ENSP00000261486	ENSP00000361646	erythrocyte membrane protein band 4.1 like 4A	zinc finger, MYND-type containing 12	0.501
FBXO18	ARHGAP21	ENSP00000369335	ENSP00000379709	F-box protein, helicase, 18	Rho GTPase activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions	0.490

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