VPS13C protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

VPS13C

vacuolar protein sorting 13 homolog C (S. cerevisiae) (3753 aa)

Predicted Functional Partners:

UBC

0.959

PCSK1

0.809

PCSK5

0.805

PCSK7

0.805

PCSK6

0.805

PCSK4

0.805

FURIN

0.805

PCSK2

0.805

CALM2

0.737

WDR78

0.645

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALM2	UBC	ENSP00000272298	ENSP00000344818	calmodulin 2 (phosphorylase kinase, delta)	ubiquitin C	0.978
CALM2	VPS13C	ENSP00000272298	ENSP00000261517	calmodulin 2 (phosphorylase kinase, delta)	vacuolar protein sorting 13 homolog C (S. cerevisiae)	0.737
FURIN	PCSK5	ENSP00000268171	ENSP00000446280	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins	0.931
FURIN	PCSK6	ENSP00000268171	ENSP00000305056	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	proprotein convertase subtilisin/kexin type 6	0.932
FURIN	PCSK7	ENSP00000268171	ENSP00000325917	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif	0.459
FURIN	UBC	ENSP00000268171	ENSP00000344818	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	ubiquitin C	0.666
FURIN	VPS13C	ENSP00000268171	ENSP00000261517	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	vacuolar protein sorting 13 homolog C (S. cerevisiae)	0.805
PCSK1	PCSK7	ENSP00000308024	ENSP00000325917	proprotein convertase subtilisin/kexin type 1; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin	proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif	0.429
PCSK1	VPS13C	ENSP00000308024	ENSP00000261517	proprotein convertase subtilisin/kexin type 1; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin	vacuolar protein sorting 13 homolog C (S. cerevisiae)	0.809
PCSK2	PCSK7	ENSP00000262545	ENSP00000325917	proprotein convertase subtilisin/kexin type 2	proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif	0.430
PCSK2	VPS13C	ENSP00000262545	ENSP00000261517	proprotein convertase subtilisin/kexin type 2	vacuolar protein sorting 13 homolog C (S. cerevisiae)	0.805
PCSK4	PCSK7	ENSP00000300954	ENSP00000325917	proprotein convertase subtilisin/kexin type 4; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex	proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif	0.433
PCSK4	VPS13C	ENSP00000300954	ENSP00000261517	proprotein convertase subtilisin/kexin type 4; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex	vacuolar protein sorting 13 homolog C (S. cerevisiae)	0.805
PCSK5	FURIN	ENSP00000446280	ENSP00000268171	proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	0.931
PCSK5	PCSK6	ENSP00000446280	ENSP00000305056	proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins	proprotein convertase subtilisin/kexin type 6	0.930
PCSK5	PCSK7	ENSP00000446280	ENSP00000325917	proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins	proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif	0.402
PCSK5	VPS13C	ENSP00000446280	ENSP00000261517	proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins	vacuolar protein sorting 13 homolog C (S. cerevisiae)	0.805
PCSK6	FURIN	ENSP00000305056	ENSP00000268171	proprotein convertase subtilisin/kexin type 6	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	0.932
PCSK6	PCSK5	ENSP00000305056	ENSP00000446280	proprotein convertase subtilisin/kexin type 6	proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins	0.930
PCSK6	PCSK7	ENSP00000305056	ENSP00000325917	proprotein convertase subtilisin/kexin type 6	proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif	0.400

page 1 of 3

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Fusion

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About