KIAA0556 protein (Homo sapiens) - STRING network view

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KIAA0556

KIAA0556 (1618 aa)

Predicted Functional Partners:

DHODH

0.652

DNAH5

0.644

GTF3C1

0.643

TMEM192

0.619

RFXANK

0.611

KIAA0753

0.547

XAF1

0.547

DNAH8

0.538

C9orf89

0.489

ATXN1L

0.485

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATXN1L	KIAA0556	ENSP00000415822	ENSP00000261588	ataxin 1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity)	KIAA0556	0.485
C9orf89	KIAA0556	ENSP00000364613	ENSP00000261588	chromosome 9 open reading frame 89; Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner	KIAA0556	0.489
DHODH	DNAH5	ENSP00000219240	ENSP00000265104	dihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	dynein, axonemal, heavy chain 5; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles	0.569
DHODH	DNAH8	ENSP00000219240	ENSP00000333363	dihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	dynein, axonemal, heavy chain 8; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity)	0.557
DHODH	KIAA0556	ENSP00000219240	ENSP00000261588	dihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	KIAA0556	0.652
DNAH5	DHODH	ENSP00000265104	ENSP00000219240	dynein, axonemal, heavy chain 5; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles	dihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	0.569
DNAH5	DNAH8	ENSP00000265104	ENSP00000333363	dynein, axonemal, heavy chain 5; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles	dynein, axonemal, heavy chain 8; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity)	0.900
DNAH5	KIAA0556	ENSP00000265104	ENSP00000261588	dynein, axonemal, heavy chain 5; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles	KIAA0556	0.644
DNAH8	DHODH	ENSP00000333363	ENSP00000219240	dynein, axonemal, heavy chain 8; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity)	dihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	0.557
DNAH8	DNAH5	ENSP00000333363	ENSP00000265104	dynein, axonemal, heavy chain 8; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity)	dynein, axonemal, heavy chain 5; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles	0.900
DNAH8	KIAA0556	ENSP00000333363	ENSP00000261588	dynein, axonemal, heavy chain 8; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity)	KIAA0556	0.538
GTF3C1	KIAA0556	ENSP00000348510	ENSP00000261588	general transcription factor IIIC, polypeptide 1, alpha 220kDa; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element	KIAA0556	0.643
KIAA0556	ATXN1L	ENSP00000261588	ENSP00000415822	KIAA0556	ataxin 1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1) (By similarity)	0.485
KIAA0556	C9orf89	ENSP00000261588	ENSP00000364613	KIAA0556	chromosome 9 open reading frame 89; Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner	0.489
KIAA0556	DHODH	ENSP00000261588	ENSP00000219240	KIAA0556	dihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	0.652
KIAA0556	DNAH5	ENSP00000261588	ENSP00000265104	KIAA0556	dynein, axonemal, heavy chain 5; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles	0.644
KIAA0556	DNAH8	ENSP00000261588	ENSP00000333363	KIAA0556	dynein, axonemal, heavy chain 8; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity)	0.538
KIAA0556	GTF3C1	ENSP00000261588	ENSP00000348510	KIAA0556	general transcription factor IIIC, polypeptide 1, alpha 220kDa; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element	0.643
KIAA0556	KIAA0753	ENSP00000261588	ENSP00000355250	KIAA0556	KIAA0753	0.547
KIAA0556	RFXANK	ENSP00000261588	ENSP00000305071	KIAA0556	regulatory factor X-associated ankyrin-containing protein; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes	0.611

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