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WASH6P WASH6P MST4 MST4 LEF1 LEF1 TCF4 TCF4 RNF138 RNF138 SPAG8 SPAG8 HSD11B2 HSD11B2 TRIM8 TRIM8 C6orf165 C6orf165 UBE2K UBE2K LNX2 LNX2
"RNF138" - ring finger protein 138, E3 ubiquitin protein ligase in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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second shell of interactors
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Predicted Interactions
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fusion edge
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protein homology
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RNF138ring finger protein 138, E3 ubiquitin protein ligase; E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (245 aa)    
Predicted Functional Partners:
UBE2K
ubiquitin-conjugating enzyme E2K (200 aa)
       score_image score_image   score_image   0.904
TCF4
transcription factor 4 (671 aa)
         score_image       0.566
LEF1
lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 [...] (399 aa)
         score_image   score_image   0.566
MST4
Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis (416 aa)
             score_image   0.512
HSD11B2
hydroxysteroid (11-beta) dehydrogenase 2 (405 aa)
             score_image   0.507
C6orf165
chromosome 6 open reading frame 165 (622 aa)
         score_image       0.506
WASH6P
WAS protein family homolog 6 pseudogene; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting (By similarity) (478 aa)
             score_image   0.486
SPAG8
sperm associated antigen 8; May play a role in fertility and microtubule formation through interaction with RANBP9 (501 aa)
             score_image   0.472
LNX2
ligand of numb-protein X 2 (690 aa)
         score_image       0.461
TRIM8
tripartite motif containing 8; Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1 (By similarity) (551 aa)
         score_image       0.461
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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