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RAB6B RAB6B COG6 COG6 RAB6A RAB6A RAB6C RAB6C GCC2 GCC2 ARL1 ARL1 GOLGA4 GOLGA4 MON2 MON2 GRIP1 GRIP1 ARFIP2 ARFIP2 ARFGAP1 ARFGAP1
"ARL1" - ADP-ribosylation factor-like 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
ARL1ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (181 aa)    
Predicted Functional Partners:
ARFIP2
ADP-ribosylation factor interacting protein 2; Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling (341 aa)
        score_image   score_image   0.996
GOLGA4
golgin A4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1 (2243 aa)
        score_image   score_image   0.983
MON2
MON2 homolog (S. cerevisiae); May be required for traffic between late Golgi and early endosomes (By similarity) (1717 aa)
        score_image   score_image   0.978
ARFGAP1
ADP-ribosylation factor GTPase activating protein 1 (414 aa)
        score_image   score_image   0.900
COG6
component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) (657 aa)
        score_image   score_image   0.859
GRIP1
glutamate receptor interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (1076 aa)
            score_image   0.836
GCC2
GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 (1684 aa)
        score_image   score_image   0.820
RAB6C
RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression (254 aa)
      score_image score_image   score_image   0.782
RAB6A
RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity (208 aa)
      score_image score_image   score_image   0.782
RAB6B
RAB6B, member RAS oncogene family; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (208 aa)
      score_image score_image   score_image   0.782
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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