node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARFGAP1 | ARL1 | ENSP00000314615 | ENSP00000261636 | ADP-ribosylation factor GTPase activating protein 1 | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | 0.900 |
ARFGAP1 | MON2 | ENSP00000314615 | ENSP00000377252 | ADP-ribosylation factor GTPase activating protein 1 | MON2 homolog (S. cerevisiae); May be required for traffic between late Golgi and early endosomes (By similarity) | 0.485 |
ARFIP2 | ARL1 | ENSP00000254584 | ENSP00000261636 | ADP-ribosylation factor interacting protein 2; Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | 0.996 |
ARL1 | ARFGAP1 | ENSP00000261636 | ENSP00000314615 | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | ADP-ribosylation factor GTPase activating protein 1 | 0.900 |
ARL1 | ARFIP2 | ENSP00000261636 | ENSP00000254584 | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | ADP-ribosylation factor interacting protein 2; Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling | 0.996 |
ARL1 | COG6 | ENSP00000261636 | ENSP00000397441 | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | 0.859 |
ARL1 | GCC2 | ENSP00000261636 | ENSP00000307939 | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 | 0.820 |
ARL1 | GOLGA4 | ENSP00000261636 | ENSP00000349305 | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | golgin A4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1 | 0.983 |
ARL1 | GRIP1 | ENSP00000261636 | ENSP00000381098 | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | glutamate receptor interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons | 0.836 |
ARL1 | MON2 | ENSP00000261636 | ENSP00000377252 | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | MON2 homolog (S. cerevisiae); May be required for traffic between late Golgi and early endosomes (By similarity) | 0.978 |
ARL1 | RAB6A | ENSP00000261636 | ENSP00000311449 | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity | 0.782 |
ARL1 | RAB6B | ENSP00000261636 | ENSP00000285208 | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | RAB6B, member RAS oncogene family; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells | 0.782 |
ARL1 | RAB6C | ENSP00000261636 | ENSP00000387307 | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression | 0.782 |
COG6 | ARL1 | ENSP00000397441 | ENSP00000261636 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | 0.859 |
COG6 | RAB6A | ENSP00000397441 | ENSP00000311449 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | RAB6A, member RAS oncogene family; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity | 0.493 |
COG6 | RAB6B | ENSP00000397441 | ENSP00000285208 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | RAB6B, member RAS oncogene family; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells | 0.428 |
COG6 | RAB6C | ENSP00000397441 | ENSP00000387307 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | RAB6C, member RAS oncogene family; May be involved in the regulation of centrosome duplication and cell cycle progression | 0.428 |
GCC2 | ARL1 | ENSP00000307939 | ENSP00000261636 | GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 | ADP-ribosylation factor-like 1; GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus | 0.820 |
GCC2 | GOLGA4 | ENSP00000307939 | ENSP00000349305 | GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 | golgin A4; May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1 | 0.776 |
GCC2 | GRIP1 | ENSP00000307939 | ENSP00000381098 | GRIP and coiled-coil domain containing 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2 | glutamate receptor interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons | 0.861 |