GPR133 protein (Homo sapiens) - STRING network view

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GPR133

G protein-coupled receptor 133; Orphan receptor (874 aa)

Predicted Functional Partners:

SBF2

0.682

LIN28B

0.681

NPPC

0.681

MCM6

0.654

OR52E4

0.633

FLNB

0.606

ADRB1

0.605

FAM154A

0.565

ENSG00000264813

0.561

OR1J4

0.501

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRB1	GPR133	ENSP00000358301	ENSP00000261654	adrenoceptor beta 1; Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity	G protein-coupled receptor 133; Orphan receptor	0.605
ENSG00000264813	GPR133	ENSP00000464149	ENSP00000261654	Angiotensin-converting enzyme; Uncharacterized protein	G protein-coupled receptor 133; Orphan receptor	0.561
ENSG00000264813	LIN28B	ENSP00000464149	ENSP00000344401	Angiotensin-converting enzyme; Uncharacterized protein	lin-28 homolog B (C. elegans); Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5’-GGAG-3’ motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5’-GGAG-3’ motif in the terminal loop, leading to their terminal uridylation [...]	0.457
ENSG00000264813	MCM6	ENSP00000464149	ENSP00000264156	Angiotensin-converting enzyme; Uncharacterized protein	minichromosome maintenance complex component 6; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...]	0.408
ENSG00000264813	NPPC	ENSP00000464149	ENSP00000295440	Angiotensin-converting enzyme; Uncharacterized protein	natriuretic peptide C; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity)	0.457
ENSG00000264813	SBF2	ENSP00000464149	ENSP00000256190	Angiotensin-converting enzyme; Uncharacterized protein	SET binding factor 2	0.459
FAM154A	GPR133	ENSP00000369907	ENSP00000261654	family with sequence similarity 154, member A	G protein-coupled receptor 133; Orphan receptor	0.565
FLNB	GPR133	ENSP00000420213	ENSP00000261654	filamin B, beta	G protein-coupled receptor 133; Orphan receptor	0.606
FLNB	LIN28B	ENSP00000420213	ENSP00000344401	filamin B, beta	lin-28 homolog B (C. elegans); Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5’-GGAG-3’ motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5’-GGAG-3’ motif in the terminal loop, leading to their terminal uridylation [...]	0.493
FLNB	MCM6	ENSP00000420213	ENSP00000264156	filamin B, beta	minichromosome maintenance complex component 6; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...]	0.440
FLNB	NPPC	ENSP00000420213	ENSP00000295440	filamin B, beta	natriuretic peptide C; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity)	0.497
FLNB	SBF2	ENSP00000420213	ENSP00000256190	filamin B, beta	SET binding factor 2	0.516
GPR133	ADRB1	ENSP00000261654	ENSP00000358301	G protein-coupled receptor 133; Orphan receptor	adrenoceptor beta 1; Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity	0.605
GPR133	ENSG00000264813	ENSP00000261654	ENSP00000464149	G protein-coupled receptor 133; Orphan receptor	Angiotensin-converting enzyme; Uncharacterized protein	0.561
GPR133	FAM154A	ENSP00000261654	ENSP00000369907	G protein-coupled receptor 133; Orphan receptor	family with sequence similarity 154, member A	0.565
GPR133	FLNB	ENSP00000261654	ENSP00000420213	G protein-coupled receptor 133; Orphan receptor	filamin B, beta	0.606
GPR133	LIN28B	ENSP00000261654	ENSP00000344401	G protein-coupled receptor 133; Orphan receptor	lin-28 homolog B (C. elegans); Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5’-GGAG-3’ motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5’-GGAG-3’ motif in the terminal loop, leading to their terminal uridylation [...]	0.681
GPR133	MCM6	ENSP00000261654	ENSP00000264156	G protein-coupled receptor 133; Orphan receptor	minichromosome maintenance complex component 6; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...]	0.654
GPR133	NPPC	ENSP00000261654	ENSP00000295440	G protein-coupled receptor 133; Orphan receptor	natriuretic peptide C; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity)	0.681
GPR133	OR1J4	ENSP00000261654	ENSP00000343521	G protein-coupled receptor 133; Orphan receptor	olfactory receptor, family 1, subfamily J, member 4; Odorant receptor (Potential)	0.501

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