MPP5 protein (Homo sapiens) - STRING network view

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MPP5

membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity) (675 aa)

Predicted Functional Partners:

INADL

0.999

AMOT

0.998

LIN7A

0.997

MPDZ

0.991

CRB3

0.984

CRB1

0.978

CRB2

0.974

LIN7C

0.955

PARD6A

0.950

PARD6B

0.947

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMOT	INADL	ENSP00000361027	ENSP00000360200	angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions	InaD-like (Drosophila)	0.942
AMOT	LIN7A	ENSP00000361027	ENSP00000447488	angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions	lin-7 homolog A (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...]	0.796
AMOT	LIN7C	ENSP00000361027	ENSP00000278193	angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions	lin-7 homolog C (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...]	0.958
AMOT	MPDZ	ENSP00000361027	ENSP00000370410	angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions	multiple PDZ domain protein	0.988
AMOT	MPP5	ENSP00000361027	ENSP00000261681	angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity)	0.998
CRB1	CRB2	ENSP00000356370	ENSP00000362734	crumbs homolog 1 (Drosophila)	crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis	0.826
CRB1	CRB3	ENSP00000356370	ENSP00000349204	crumbs homolog 1 (Drosophila)	crumbs homolog 3 (Drosophila); Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions	0.746
CRB1	INADL	ENSP00000356370	ENSP00000360200	crumbs homolog 1 (Drosophila)	InaD-like (Drosophila)	0.887
CRB1	LIN7A	ENSP00000356370	ENSP00000447488	crumbs homolog 1 (Drosophila)	lin-7 homolog A (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...]	0.492
CRB1	MPDZ	ENSP00000356370	ENSP00000370410	crumbs homolog 1 (Drosophila)	multiple PDZ domain protein	0.503
CRB1	MPP5	ENSP00000356370	ENSP00000261681	crumbs homolog 1 (Drosophila)	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity)	0.978
CRB1	PARD6A	ENSP00000356370	ENSP00000219255	crumbs homolog 1 (Drosophila)	par-6 partitioning defective 6 homolog alpha (C. elegans); Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins	0.453
CRB2	CRB1	ENSP00000362734	ENSP00000356370	crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis	crumbs homolog 1 (Drosophila)	0.826
CRB2	CRB3	ENSP00000362734	ENSP00000349204	crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis	crumbs homolog 3 (Drosophila); Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions	0.748
CRB2	INADL	ENSP00000362734	ENSP00000360200	crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis	InaD-like (Drosophila)	0.897
CRB2	LIN7A	ENSP00000362734	ENSP00000447488	crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis	lin-7 homolog A (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...]	0.433
CRB2	LIN7C	ENSP00000362734	ENSP00000278193	crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis	lin-7 homolog C (C. elegans); Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may [...]	0.504
CRB2	MPDZ	ENSP00000362734	ENSP00000370410	crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis	multiple PDZ domain protein	0.889
CRB2	MPP5	ENSP00000362734	ENSP00000261681	crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity)	0.974
CRB2	PARD6A	ENSP00000362734	ENSP00000219255	crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis	par-6 partitioning defective 6 homolog alpha (C. elegans); Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins	0.776

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