node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C14orf166 | C22orf28 | ENSP00000261700 | ENSP00000216038 | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | chromosome 22 open reading frame 28; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3’,5’- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs | 0.999 |
C14orf166 | C2orf49 | ENSP00000261700 | ENSP00000258457 | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | chromosome 2 open reading frame 49 | 0.999 |
C14orf166 | DDX1 | ENSP00000261700 | ENSP00000233084 | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] | 0.999 |
C14orf166 | FAM82A2 | ENSP00000261700 | ENSP00000260385 | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | family with sequence similarity 82, member A2; Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis | 0.865 |
C14orf166 | FAM98A | ENSP00000261700 | ENSP00000238823 | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | family with sequence similarity 98, member A | 0.929 |
C14orf166 | FAM98B | ENSP00000261700 | ENSP00000380734 | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | family with sequence similarity 98, member B | 0.999 |
C14orf166 | ILF2 | ENSP00000261700 | ENSP00000355011 | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus | 0.709 |
C14orf166 | NIN | ENSP00000261700 | ENSP00000371472 | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | ninein (GSK3B interacting protein) | 0.893 |
C14orf166 | POLR2A | ENSP00000261700 | ENSP00000314949 | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the cen [...] | 0.826 |
C14orf166 | UBC | ENSP00000261700 | ENSP00000344818 | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | ubiquitin C | 0.944 |
C22orf28 | C14orf166 | ENSP00000216038 | ENSP00000261700 | chromosome 22 open reading frame 28; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3’,5’- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | 0.999 |
C22orf28 | C2orf49 | ENSP00000216038 | ENSP00000258457 | chromosome 22 open reading frame 28; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3’,5’- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs | chromosome 2 open reading frame 49 | 0.999 |
C22orf28 | DDX1 | ENSP00000216038 | ENSP00000233084 | chromosome 22 open reading frame 28; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3’,5’- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs | DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] | 0.997 |
C22orf28 | FAM98A | ENSP00000216038 | ENSP00000238823 | chromosome 22 open reading frame 28; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3’,5’- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs | family with sequence similarity 98, member A | 0.651 |
C22orf28 | FAM98B | ENSP00000216038 | ENSP00000380734 | chromosome 22 open reading frame 28; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3’,5’- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs | family with sequence similarity 98, member B | 0.999 |
C22orf28 | ILF2 | ENSP00000216038 | ENSP00000355011 | chromosome 22 open reading frame 28; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3’,5’- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs | interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus | 0.485 |
C22orf28 | UBC | ENSP00000216038 | ENSP00000344818 | chromosome 22 open reading frame 28; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3’,5’- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs | ubiquitin C | 0.981 |
C2orf49 | C14orf166 | ENSP00000258457 | ENSP00000261700 | chromosome 2 open reading frame 49 | chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication | 0.999 |
C2orf49 | C22orf28 | ENSP00000258457 | ENSP00000216038 | chromosome 2 open reading frame 49 | chromosome 22 open reading frame 28; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3’,5’- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs | 0.999 |
C2orf49 | DDX1 | ENSP00000258457 | ENSP00000233084 | chromosome 2 open reading frame 49 | DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] | 0.992 |