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STRINGSTRING
POLR2A POLR2A ILF2 ILF2 UBC UBC NIN NIN FAM98A FAM98A C14orf166 C14orf166 C22orf28 C22orf28 DDX1 DDX1 FAM82A2 FAM82A2 FAM98B FAM98B C2orf49 C2orf49
"C14orf166" - chromosome 14 open reading frame 166 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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second shell of interactors
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Predicted Interactions
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protein homology
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C14orf166chromosome 14 open reading frame 166; Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication (244 aa)    
Predicted Functional Partners:
FAM98B
family with sequence similarity 98, member B (433 aa)
        score_image score_image score_image   0.999
C22orf28
chromosome 22 open reading frame 28; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3’,5’- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs (505 aa)
        score_image score_image score_image   0.999
DDX1
DEAD (Asp-Glu-Ala-Asp) box helicase 1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5’ single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 ex [...] (740 aa)
        score_image score_image score_image   0.999
C2orf49
chromosome 2 open reading frame 49 (232 aa)
        score_image score_image score_image   0.999
UBC
ubiquitin C (685 aa)
        score_image       0.944
FAM98A
family with sequence similarity 98, member A (518 aa)
        score_image   score_image   0.929
NIN
ninein (GSK3B interacting protein) (2090 aa)
        score_image   score_image   0.893
FAM82A2
family with sequence similarity 82, member A2; Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (470 aa)
            score_image   0.865
POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the cen [...] (1970 aa)
        score_image   score_image   0.826
ILF2
interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus (390 aa)
        score_image   score_image   0.709
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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