BTBD1 protein (Homo sapiens) - STRING network view

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BTBD1

BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (482 aa)

Predicted Functional Partners:

TOP1

0.986

TRIM5

0.939

CUL3

0.924

COPS6

0.770

UBC

0.721

TRIM17

0.583

BTBD2

0.570

TRIM6

0.511

ENSG00000258588

0.495

LONP2

0.493

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTBD1	BTBD2	ENSP00000261721	ENSP00000255608	BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	BTB (POZ) domain containing 2	0.570
BTBD1	COPS6	ENSP00000261721	ENSP00000304102	BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...]	0.770
BTBD1	CUL3	ENSP00000261721	ENSP00000264414	BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...]	0.924
BTBD1	ENSG00000258588	ENSP00000261721	ENSP00000346916	BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	TRIM6-TRIM34 readthrough	0.495
BTBD1	LONP2	ENSP00000261721	ENSP00000285737	BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	lon peptidase 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1	0.493
BTBD1	TOP1	ENSP00000261721	ENSP00000354522	BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	topoisomerase (DNA) I	0.986
BTBD1	TRIM17	ENSP00000261721	ENSP00000295033	BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	tripartite motif containing 17; May function as an ubiquitin E3 ligase	0.583
BTBD1	TRIM5	ENSP00000261721	ENSP00000369373	BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	tripartite motif containing 5	0.939
BTBD1	TRIM6	ENSP00000261721	ENSP00000369440	BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	tripartite motif containing 6	0.511
BTBD1	UBC	ENSP00000261721	ENSP00000344818	BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	ubiquitin C	0.721
BTBD2	BTBD1	ENSP00000255608	ENSP00000261721	BTB (POZ) domain containing 2	BTB (POZ) domain containing 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins	0.570
BTBD2	COPS6	ENSP00000255608	ENSP00000304102	BTB (POZ) domain containing 2	COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...]	0.903
BTBD2	CUL3	ENSP00000255608	ENSP00000264414	BTB (POZ) domain containing 2	cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...]	0.876
BTBD2	ENSG00000258588	ENSP00000255608	ENSP00000346916	BTB (POZ) domain containing 2	TRIM6-TRIM34 readthrough	0.495
BTBD2	LONP2	ENSP00000255608	ENSP00000285737	BTB (POZ) domain containing 2	lon peptidase 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1	0.580
BTBD2	TOP1	ENSP00000255608	ENSP00000354522	BTB (POZ) domain containing 2	topoisomerase (DNA) I	0.986
BTBD2	TRIM17	ENSP00000255608	ENSP00000295033	BTB (POZ) domain containing 2	tripartite motif containing 17; May function as an ubiquitin E3 ligase	0.581
BTBD2	TRIM5	ENSP00000255608	ENSP00000369373	BTB (POZ) domain containing 2	tripartite motif containing 5	0.939
BTBD2	TRIM6	ENSP00000255608	ENSP00000369440	BTB (POZ) domain containing 2	tripartite motif containing 6	0.511
BTBD2	UBC	ENSP00000255608	ENSP00000344818	BTB (POZ) domain containing 2	ubiquitin C	0.620

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