| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BCL6 | CUX2 | ENSP00000232014 | ENSP00000261726 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) | 0.830 |
| BCL6 | NOTCH1 | ENSP00000232014 | ENSP00000277541 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.443 |
| CSNK2A1 | CUX2 | ENSP00000217244 | ENSP00000261726 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) | 0.576 |
| CUX2 | BCL6 | ENSP00000261726 | ENSP00000232014 | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | 0.830 |
| CUX2 | CSNK2A1 | ENSP00000261726 | ENSP00000217244 | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | 0.576 |
| CUX2 | FAM109A | ENSP00000261726 | ENSP00000354461 | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) | family with sequence similarity 109, member A; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane | 0.681 |
| CUX2 | IGSF9B | ENSP00000261726 | ENSP00000317980 | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) | immunoglobulin superfamily, member 9B | 0.558 |
| CUX2 | MAFK | ENSP00000261726 | ENSP00000344903 | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) | v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian); Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor | 0.593 |
| CUX2 | NOTCH1 | ENSP00000261726 | ENSP00000277541 | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.848 |
| CUX2 | RACGAP1 | ENSP00000261726 | ENSP00000309871 | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) | Rac GTPase activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase acti [...] | 0.684 |
| CUX2 | SLC4A4 | ENSP00000261726 | ENSP00000393557 | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) | solute carrier family 4, sodium bicarbonate cotransporter, member 4 | 0.584 |
| CUX2 | TBR1 | ENSP00000261726 | ENSP00000374205 | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) | T-box, brain, 1; Probable transcriptional regulator involved in developmental processes. TBR1 is required for normal brain development | 0.648 |
| CUX2 | TSPEAR | ENSP00000261726 | ENSP00000321987 | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) | thrombospondin-type laminin G domain and EAR repeats; May play a role in development or function of the auditory system | 0.658 |
| FAM109A | CUX2 | ENSP00000354461 | ENSP00000261726 | family with sequence similarity 109, member A; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) | 0.681 |
| FAM109A | SLC4A4 | ENSP00000354461 | ENSP00000393557 | family with sequence similarity 109, member A; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane | solute carrier family 4, sodium bicarbonate cotransporter, member 4 | 0.606 |
| FAM109A | TSPEAR | ENSP00000354461 | ENSP00000321987 | family with sequence similarity 109, member A; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane | thrombospondin-type laminin G domain and EAR repeats; May play a role in development or function of the auditory system | 0.662 |
| IGSF9B | CUX2 | ENSP00000317980 | ENSP00000261726 | immunoglobulin superfamily, member 9B | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) | 0.558 |
| MAFK | CUX2 | ENSP00000344903 | ENSP00000261726 | v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian); Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) | 0.593 |
| NOTCH1 | BCL6 | ENSP00000277541 | ENSP00000232014 | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | 0.443 |
| NOTCH1 | CUX2 | ENSP00000277541 | ENSP00000261726 | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | cut-like homeobox 2; May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner (By similarity) | 0.848 |
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