node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | ACSS1 | ENSP00000253792 | ENSP00000316924 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | acyl-CoA synthetase short-chain family member 1 | 0.931 |
ACLY | ALDH2 | ENSP00000253792 | ENSP00000261733 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | aldehyde dehydrogenase 2 family (mitochondrial) | 0.725 |
ACSS1 | ACLY | ENSP00000316924 | ENSP00000253792 | acyl-CoA synthetase short-chain family member 1 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.931 |
ACSS1 | ADH1A | ENSP00000316924 | ENSP00000209668 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 1A (class I), alpha polypeptide | 0.549 |
ACSS1 | ADH1B | ENSP00000316924 | ENSP00000306606 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.486 |
ACSS1 | ADH4 | ENSP00000316924 | ENSP00000265512 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 4 (class II), pi polypeptide | 0.538 |
ACSS1 | ADH6 | ENSP00000316924 | ENSP00000378359 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 6 (class V) | 0.549 |
ACSS1 | ADH7 | ENSP00000316924 | ENSP00000420269 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | 0.549 |
ACSS1 | ALDH2 | ENSP00000316924 | ENSP00000261733 | acyl-CoA synthetase short-chain family member 1 | aldehyde dehydrogenase 2 family (mitochondrial) | 0.953 |
ACSS1 | SIRT3 | ENSP00000316924 | ENSP00000372191 | acyl-CoA synthetase short-chain family member 1 | sirtuin 3; NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels | 0.950 |
ADH1A | ACSS1 | ENSP00000209668 | ENSP00000316924 | alcohol dehydrogenase 1A (class I), alpha polypeptide | acyl-CoA synthetase short-chain family member 1 | 0.549 |
ADH1A | ALDH2 | ENSP00000209668 | ENSP00000261733 | alcohol dehydrogenase 1A (class I), alpha polypeptide | aldehyde dehydrogenase 2 family (mitochondrial) | 0.795 |
ADH1A | CYP2E1 | ENSP00000209668 | ENSP00000252945 | alcohol dehydrogenase 1A (class I), alpha polypeptide | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | 0.936 |
ADH1B | ACSS1 | ENSP00000306606 | ENSP00000316924 | alcohol dehydrogenase 1B (class I), beta polypeptide | acyl-CoA synthetase short-chain family member 1 | 0.486 |
ADH1B | ALDH2 | ENSP00000306606 | ENSP00000261733 | alcohol dehydrogenase 1B (class I), beta polypeptide | aldehyde dehydrogenase 2 family (mitochondrial) | 0.926 |
ADH1B | CYP2E1 | ENSP00000306606 | ENSP00000252945 | alcohol dehydrogenase 1B (class I), beta polypeptide | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | 0.972 |
ADH4 | ACSS1 | ENSP00000265512 | ENSP00000316924 | alcohol dehydrogenase 4 (class II), pi polypeptide | acyl-CoA synthetase short-chain family member 1 | 0.538 |
ADH4 | ADH7 | ENSP00000265512 | ENSP00000420269 | alcohol dehydrogenase 4 (class II), pi polypeptide | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | 0.591 |
ADH4 | ALDH2 | ENSP00000265512 | ENSP00000261733 | alcohol dehydrogenase 4 (class II), pi polypeptide | aldehyde dehydrogenase 2 family (mitochondrial) | 0.899 |
ADH4 | CYP2E1 | ENSP00000265512 | ENSP00000252945 | alcohol dehydrogenase 4 (class II), pi polypeptide | cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms | 0.963 |