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STRINGSTRING
PRKCE PRKCE SIRT3 SIRT3 ALDH2 ALDH2 ADH6 ADH6 ACSS1 ACSS1 ACLY ACLY ADH1B ADH1B CYP2E1 CYP2E1 ADH1A ADH1A ADH4 ADH4 ADH7 ADH7
"ALDH2" - aldehyde dehydrogenase 2 family in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
ALDH2aldehyde dehydrogenase 2 family (mitochondrial) (517 aa)    
Predicted Functional Partners:
ACSS1
acyl-CoA synthetase short-chain family member 1 (689 aa)
      score_image score_image score_image score_image   0.953
SIRT3
sirtuin 3; NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels (399 aa)
        score_image   score_image   0.927
ADH1B
alcohol dehydrogenase 1B (class I), beta polypeptide (375 aa)
            score_image   0.926
ADH4
alcohol dehydrogenase 4 (class II), pi polypeptide (380 aa)
            score_image   0.899
PRKCE
protein kinase C, epsilon; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITG [...] (737 aa)
            score_image   0.887
ADH1A
alcohol dehydrogenase 1A (class I), alpha polypeptide (375 aa)
            score_image   0.795
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism (394 aa)
            score_image   0.773
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1; Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms (493 aa)
        score_image   score_image   0.737
ADH6
alcohol dehydrogenase 6 (class V) (375 aa)
            score_image   0.726
ACLY
ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
score_image     score_image     score_image   0.725
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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