| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADC | ARG2 | ENSP00000294517 | ENSP00000261783 | arginine decarboxylase | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | 0.957 |
| ADC | ENSG00000249319 | ENSP00000294517 | ENSP00000396527 | arginine decarboxylase | Uncharacterized protein | 0.954 |
| ADC | NOS1 | ENSP00000294517 | ENSP00000337459 | arginine decarboxylase | nitric oxide synthase 1 (neuronal); Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR | 0.916 |
| ADC | NOS2 | ENSP00000294517 | ENSP00000327251 | arginine decarboxylase | nitric oxide synthase 2, inducible | 0.914 |
| ADC | NOS3 | ENSP00000294517 | ENSP00000297494 | arginine decarboxylase | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | 0.920 |
| ADC | OAT | ENSP00000294517 | ENSP00000357838 | arginine decarboxylase | ornithine aminotransferase | 0.652 |
| ADC | OTC | ENSP00000294517 | ENSP00000039007 | arginine decarboxylase | ornithine carbamoyltransferase | 0.603 |
| ARG2 | ADC | ENSP00000261783 | ENSP00000294517 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | arginine decarboxylase | 0.957 |
| ARG2 | ENSG00000114786 | ENSP00000261783 | ENSP00000420487 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | ABHD14A-ACY1 readthrough (non-protein coding) | 0.912 |
| ARG2 | ENSG00000249319 | ENSP00000261783 | ENSP00000396527 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | Uncharacterized protein | 0.924 |
| ARG2 | NOS1 | ENSP00000261783 | ENSP00000337459 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | nitric oxide synthase 1 (neuronal); Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR | 0.914 |
| ARG2 | NOS2 | ENSP00000261783 | ENSP00000327251 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | nitric oxide synthase 2, inducible | 0.940 |
| ARG2 | NOS3 | ENSP00000261783 | ENSP00000297494 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) | 0.985 |
| ARG2 | OAT | ENSP00000261783 | ENSP00000357838 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | ornithine aminotransferase | 0.986 |
| ARG2 | ODC1 | ENSP00000261783 | ENSP00000234111 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | ornithine decarboxylase 1 | 0.959 |
| ARG2 | OTC | ENSP00000261783 | ENSP00000039007 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | ornithine carbamoyltransferase | 0.964 |
| ARG2 | PRMT6 | ENSP00000261783 | ENSP00000359095 | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | protein arginine methyltransferase 6; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 ’Arg-2’ to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on hi [...] | 0.841 |
| ENSG00000114786 | ARG2 | ENSP00000420487 | ENSP00000261783 | ABHD14A-ACY1 readthrough (non-protein coding) | arginase, type II; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders | 0.912 |
| ENSG00000114786 | OAT | ENSP00000420487 | ENSP00000357838 | ABHD14A-ACY1 readthrough (non-protein coding) | ornithine aminotransferase | 0.946 |
| ENSG00000114786 | ODC1 | ENSP00000420487 | ENSP00000234111 | ABHD14A-ACY1 readthrough (non-protein coding) | ornithine decarboxylase 1 | 0.928 |
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