| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AICDA | IPO4 | ENSP00000229335 | ENSP00000346453 | activation-induced cytidine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation | importin 4; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | 0.600 |
| AICDA | TM9SF1 | ENSP00000229335 | ENSP00000261789 | activation-induced cytidine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation | transmembrane 9 superfamily member 1; Plays an essential role in autophagy | 0.590 |
| FEN1 | IPO4 | ENSP00000305480 | ENSP00000346453 | flap structure-specific endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminat [...] | importin 4; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | 0.584 |
| FEN1 | TM9SF1 | ENSP00000305480 | ENSP00000261789 | flap structure-specific endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminat [...] | transmembrane 9 superfamily member 1; Plays an essential role in autophagy | 0.570 |
| IMPA1 | TM9SF1 | ENSP00000408526 | ENSP00000261789 | inositol(myo)-1(or 4)-monophosphatase 1; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol- phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2’-AMP as substrates | transmembrane 9 superfamily member 1; Plays an essential role in autophagy | 0.524 |
| IPO4 | AICDA | ENSP00000346453 | ENSP00000229335 | importin 4; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | activation-induced cytidine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation | 0.600 |
| IPO4 | FEN1 | ENSP00000346453 | ENSP00000305480 | importin 4; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | flap structure-specific endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminat [...] | 0.584 |
| IPO4 | SLC2A14 | ENSP00000346453 | ENSP00000379834 | importin 4; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | solute carrier family 2 (facilitated glucose transporter), member 14; Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis | 0.465 |
| IPO4 | SLC2A3 | ENSP00000346453 | ENSP00000075120 | importin 4; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | solute carrier family 2 (facilitated glucose transporter), member 3; Facilitative glucose transporter. Probably a neuronal glucose transporter | 0.475 |
| IPO4 | TM9SF1 | ENSP00000346453 | ENSP00000261789 | importin 4; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | transmembrane 9 superfamily member 1; Plays an essential role in autophagy | 0.649 |
| SLC2A14 | IPO4 | ENSP00000379834 | ENSP00000346453 | solute carrier family 2 (facilitated glucose transporter), member 14; Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis | importin 4; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | 0.465 |
| SLC2A14 | TM9SF1 | ENSP00000379834 | ENSP00000261789 | solute carrier family 2 (facilitated glucose transporter), member 14; Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis | transmembrane 9 superfamily member 1; Plays an essential role in autophagy | 0.485 |
| SLC2A3 | IPO4 | ENSP00000075120 | ENSP00000346453 | solute carrier family 2 (facilitated glucose transporter), member 3; Facilitative glucose transporter. Probably a neuronal glucose transporter | importin 4; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | 0.475 |
| SLC2A3 | TM9SF1 | ENSP00000075120 | ENSP00000261789 | solute carrier family 2 (facilitated glucose transporter), member 3; Facilitative glucose transporter. Probably a neuronal glucose transporter | transmembrane 9 superfamily member 1; Plays an essential role in autophagy | 0.488 |
| TM9SF1 | AICDA | ENSP00000261789 | ENSP00000229335 | transmembrane 9 superfamily member 1; Plays an essential role in autophagy | activation-induced cytidine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation | 0.590 |
| TM9SF1 | FEN1 | ENSP00000261789 | ENSP00000305480 | transmembrane 9 superfamily member 1; Plays an essential role in autophagy | flap structure-specific endonuclease 1; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminat [...] | 0.570 |
| TM9SF1 | IMPA1 | ENSP00000261789 | ENSP00000408526 | transmembrane 9 superfamily member 1; Plays an essential role in autophagy | inositol(myo)-1(or 4)-monophosphatase 1; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol- phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2’-AMP as substrates | 0.524 |
| TM9SF1 | IPO4 | ENSP00000261789 | ENSP00000346453 | transmembrane 9 superfamily member 1; Plays an essential role in autophagy | importin 4; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] | 0.649 |
| TM9SF1 | SLC2A14 | ENSP00000261789 | ENSP00000379834 | transmembrane 9 superfamily member 1; Plays an essential role in autophagy | solute carrier family 2 (facilitated glucose transporter), member 14; Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis | 0.485 |
| TM9SF1 | SLC2A3 | ENSP00000261789 | ENSP00000075120 | transmembrane 9 superfamily member 1; Plays an essential role in autophagy | solute carrier family 2 (facilitated glucose transporter), member 3; Facilitative glucose transporter. Probably a neuronal glucose transporter | 0.488 |
Share
