node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCL11 | IL17A | ENSP00000302234 | ENSP00000344192 | chemokine (C-C motif) ligand 11; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | 0.499 |
CCL11 | IL17B | ENSP00000302234 | ENSP00000261796 | chemokine (C-C motif) ligand 11; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 | interleukin 17B; Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1 | 0.407 |
CCL11 | IL17C | ENSP00000302234 | ENSP00000244241 | chemokine (C-C motif) ligand 11; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 | interleukin 17C; Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic [...] | 0.562 |
CCL11 | IL25 | ENSP00000302234 | ENSP00000328111 | chemokine (C-C motif) ligand 11; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 | interleukin 25; Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses | 0.610 |
IL17A | CCL11 | ENSP00000344192 | ENSP00000302234 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | chemokine (C-C motif) ligand 11; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 | 0.499 |
IL17A | IL17B | ENSP00000344192 | ENSP00000261796 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | interleukin 17B; Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1 | 0.565 |
IL17A | IL17RA | ENSP00000344192 | ENSP00000320936 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | interleukin 17 receptor A; Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling | 0.999 |
IL17A | IL17RB | ENSP00000344192 | ENSP00000288167 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | interleukin 17 receptor B; Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells | 0.474 |
IL17A | IL17RC | ENSP00000344192 | ENSP00000295981 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | interleukin 17 receptor C | 0.953 |
IL17A | IL17RD | ENSP00000344192 | ENSP00000296318 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | interleukin 17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis | 0.504 |
IL17A | IL25 | ENSP00000344192 | ENSP00000328111 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | interleukin 25; Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses | 0.720 |
IL17B | CCL11 | ENSP00000261796 | ENSP00000302234 | interleukin 17B; Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1 | chemokine (C-C motif) ligand 11; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 | 0.407 |
IL17B | IL17A | ENSP00000261796 | ENSP00000344192 | interleukin 17B; Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | 0.565 |
IL17B | IL17C | ENSP00000261796 | ENSP00000244241 | interleukin 17B; Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1 | interleukin 17C; Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic [...] | 0.812 |
IL17B | IL17RA | ENSP00000261796 | ENSP00000320936 | interleukin 17B; Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1 | interleukin 17 receptor A; Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling | 0.609 |
IL17B | IL17RB | ENSP00000261796 | ENSP00000288167 | interleukin 17B; Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1 | interleukin 17 receptor B; Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells | 0.982 |
IL17B | IL17RC | ENSP00000261796 | ENSP00000295981 | interleukin 17B; Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1 | interleukin 17 receptor C | 0.504 |
IL17B | IL17RD | ENSP00000261796 | ENSP00000296318 | interleukin 17B; Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1 | interleukin 17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis | 0.416 |
IL17B | IL25 | ENSP00000261796 | ENSP00000328111 | interleukin 17B; Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1 | interleukin 25; Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses | 0.662 |
IL17B | MUM1L1 | ENSP00000261796 | ENSP00000338641 | interleukin 17B; Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1 | melanoma associated antigen (mutated) 1-like 1 | 0.508 |