SPG11 protein (Homo sapiens) - STRING network view

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Score

SPG11

spastic paraplegia 11 (autosomal recessive) (2443 aa)

Predicted Functional Partners:

AP5Z1

0.970

ZFYVE26

0.870

AP5S1

0.868

AP5B1

0.860

UBC

0.849

CYP7B1

0.683

SEMA6D

0.672

SPG7

0.664

SPAST

0.645

SERTAD3

0.613

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AP5B1	AP5S1	ENSP00000454303	ENSP00000246041	adaptor-related protein complex 5, beta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport	adaptor-related protein complex 5, sigma 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair	0.994
AP5B1	AP5Z1	ENSP00000454303	ENSP00000297562	adaptor-related protein complex 5, beta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	0.985
AP5B1	SPG11	ENSP00000454303	ENSP00000261866	adaptor-related protein complex 5, beta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport	spastic paraplegia 11 (autosomal recessive)	0.860
AP5B1	UBC	ENSP00000454303	ENSP00000344818	adaptor-related protein complex 5, beta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport	ubiquitin C	0.854
AP5B1	ZFYVE26	ENSP00000454303	ENSP00000251119	adaptor-related protein complex 5, beta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport	zinc finger, FYVE domain containing 26	0.860
AP5S1	AP5B1	ENSP00000246041	ENSP00000454303	adaptor-related protein complex 5, sigma 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair	adaptor-related protein complex 5, beta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport	0.994
AP5S1	AP5Z1	ENSP00000246041	ENSP00000297562	adaptor-related protein complex 5, sigma 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	0.985
AP5S1	SPG11	ENSP00000246041	ENSP00000261866	adaptor-related protein complex 5, sigma 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair	spastic paraplegia 11 (autosomal recessive)	0.868
AP5S1	ZFYVE26	ENSP00000246041	ENSP00000251119	adaptor-related protein complex 5, sigma 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair	zinc finger, FYVE domain containing 26	0.860
AP5Z1	AP5B1	ENSP00000297562	ENSP00000454303	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	adaptor-related protein complex 5, beta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport	0.985
AP5Z1	AP5S1	ENSP00000297562	ENSP00000246041	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	adaptor-related protein complex 5, sigma 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862, it is required for efficient homologous recombination DNA double-strand break repair	0.985
AP5Z1	SPAST	ENSP00000297562	ENSP00000320885	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	spastin; ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and for completion of the abscission stage of cytokinesis. Also plays a role in axon growth and the formation of axonal branches (By similarity)	0.544
AP5Z1	SPG11	ENSP00000297562	ENSP00000261866	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	spastic paraplegia 11 (autosomal recessive)	0.970
AP5Z1	SPG7	ENSP00000297562	ENSP00000268704	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	spastic paraplegia 7 (pure and complicated autosomal recessive); Putative ATP-dependent zinc metalloprotease	0.402
AP5Z1	UBC	ENSP00000297562	ENSP00000344818	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	ubiquitin C	0.854
AP5Z1	ZFYVE26	ENSP00000297562	ENSP00000251119	adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair	zinc finger, FYVE domain containing 26	0.970
CYP7B1	SEMA6D	ENSP00000310721	ENSP00000324857	cytochrome P450, family 7, subfamily B, polypeptide 1	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.662
CYP7B1	SPG11	ENSP00000310721	ENSP00000261866	cytochrome P450, family 7, subfamily B, polypeptide 1	spastic paraplegia 11 (autosomal recessive)	0.683
CYP7B1	SPG7	ENSP00000310721	ENSP00000268704	cytochrome P450, family 7, subfamily B, polypeptide 1	spastic paraplegia 7 (pure and complicated autosomal recessive); Putative ATP-dependent zinc metalloprotease	0.497
CYP7B1	UBC	ENSP00000310721	ENSP00000344818	cytochrome P450, family 7, subfamily B, polypeptide 1	ubiquitin C	0.529

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