node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADORA1 | ADORA3 | ENSP00000308549 | ENSP00000358730 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | adenosine A3 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction (By similarity) | 0.921 |
ADORA1 | LTBP2 | ENSP00000308549 | ENSP00000261978 | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | latent transforming growth factor beta binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly | 0.662 |
ADORA2B | LTBP2 | ENSP00000304501 | ENSP00000261978 | adenosine A2b receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | latent transforming growth factor beta binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly | 0.520 |
ADORA3 | ADORA1 | ENSP00000358730 | ENSP00000308549 | adenosine A3 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction (By similarity) | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | 0.921 |
ADORA3 | LTBP2 | ENSP00000358730 | ENSP00000261978 | adenosine A3 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction (By similarity) | latent transforming growth factor beta binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly | 0.680 |
ADORA3 | MMP2 | ENSP00000358730 | ENSP00000219070 | adenosine A3 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction (By similarity) | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative s [...] | 0.815 |
FBLN5 | LTBP2 | ENSP00000345008 | ENSP00000261978 | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling | latent transforming growth factor beta binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly | 0.681 |
LTBP2 | ADORA1 | ENSP00000261978 | ENSP00000308549 | latent transforming growth factor beta binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly | adenosine A1 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase | 0.662 |
LTBP2 | ADORA2B | ENSP00000261978 | ENSP00000304501 | latent transforming growth factor beta binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly | adenosine A2b receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.520 |
LTBP2 | ADORA3 | ENSP00000261978 | ENSP00000358730 | latent transforming growth factor beta binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly | adenosine A3 receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction (By similarity) | 0.680 |
LTBP2 | FBLN5 | ENSP00000261978 | ENSP00000345008 | latent transforming growth factor beta binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly | fibulin 5; Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Could be a vascular ligand for integrin receptors and may play a role in vascular development and remodeling | 0.681 |
LTBP2 | MMP1 | ENSP00000261978 | ENSP00000322788 | latent transforming growth factor beta binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly | matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity | 0.541 |
LTBP2 | MMP14 | ENSP00000261978 | ENSP00000308208 | latent transforming growth factor beta binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly | matrix metallopeptidase 14 (membrane-inserted); Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 | 0.559 |
LTBP2 | MMP2 | ENSP00000261978 | ENSP00000219070 | latent transforming growth factor beta binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative s [...] | 0.571 |
LTBP2 | MMP3 | ENSP00000261978 | ENSP00000299855 | latent transforming growth factor beta binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly | matrix metallopeptidase 3 (stromelysin 1, progelatinase); Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase | 0.526 |
LTBP2 | MMP9 | ENSP00000261978 | ENSP00000361405 | latent transforming growth factor beta binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide | 0.571 |
LTBP2 | VTN | ENSP00000261978 | ENSP00000226218 | latent transforming growth factor beta binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly | vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway | 0.556 |
MMP1 | LTBP2 | ENSP00000322788 | ENSP00000261978 | matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity | latent transforming growth factor beta binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly | 0.541 |
MMP1 | MMP14 | ENSP00000322788 | ENSP00000308208 | matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity | matrix metallopeptidase 14 (membrane-inserted); Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 | 0.914 |
MMP1 | MMP2 | ENSP00000322788 | ENSP00000219070 | matrix metallopeptidase 1 (interstitial collagenase); Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat’s mediated neurotoxicity | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative s [...] | 0.924 |