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STRINGSTRING
RD6 RD6 LHX9 LHX9 NES NES ASCL1 ASCL1 KRT86 KRT86 VSX2 VSX2 POU4F2 POU4F2 CDKN1B CDKN1B PRDM1 PRDM1 MITF MITF NXNL1 NXNL1
"VSX2" - visual system homeobox 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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Predicted Interactions
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protein homology
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Score
VSX2visual system homeobox 2; Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity) (361 aa)    
Predicted Functional Partners:
ASCL1
achaete-scute complex homolog 1 (Drosophila); Transcriptional regulator. May play a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Involved in the initiation of neuronal differentiation. Mediates transcription activation by binding to the E box (5’-CANNTG-3’) (236 aa)
            score_image   0.910
NES
nestin; Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity) (1621 aa)
            score_image   0.890
MITF
microphthalmia-associated transcription factor (520 aa)
            score_image   0.877
CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1); Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1- CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry (198 aa)
            score_image   0.854
PRDM1
PR domain containing 1, with ZNF domain; Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells (825 aa)
            score_image   0.836
KRT86
keratin 86 (486 aa)
            score_image   0.812
LHX9
LIM homeobox 9; Involved in gonadal development (By similarity) (397 aa)
            score_image   0.777
POU4F2
POU class 4 homeobox 2; Transcription factor. May play a role in determining or maintaining the identities of a small subset of visual system neurons (409 aa)
            score_image   0.766
RD6
Membrane frizzled-related protein ; May play a role in eye development (579 aa)
            score_image   0.749
NXNL1
nucleoredoxin-like 1; May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (By similarity) (212 aa)
            score_image   0.749
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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