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PHF20 PHF20 PHF8 PHF8 MAPK3 MAPK3 PHF10 PHF10 FSCN3 FSCN3 PHF3 PHF3 ARHGAP28 ARHGAP28 TXNDC9 TXNDC9 YPEL5 YPEL5 TBC1D8 TBC1D8 PDCL3 PDCL3
"PHF3" - PHD finger protein 3 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
PHF3PHD finger protein 3 (2039 aa)    
Predicted Functional Partners:
PHF10
PHD finger protein 10; Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. [...] (498 aa)
            score_image   0.642
YPEL5
yippee-like 5 (Drosophila) (121 aa)
            score_image   0.543
MAPK3
mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] (379 aa)
        score_image       0.525
PHF8
PHD finger protein 8 (1060 aa)
            score_image   0.513
PHF20
PHD finger protein 20 (1012 aa)
            score_image   0.511
ARHGAP28
Rho GTPase activating protein 28; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity) (570 aa)
            score_image   0.504
TXNDC9
thioredoxin domain containing 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin (226 aa)
            score_image   0.504
TBC1D8
TBC1 domain family, member 8 (with GRAM domain); May act as a GTPase-activating protein for Rab family protein(s) (1140 aa)
            score_image   0.504
PDCL3
phosducin-like 3; Modulates the activation of caspases during apoptosis. Is a substrate for Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) IAP-mediated ubiquitination (239 aa)
            score_image   0.473
FSCN3
fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus); Acts as an actin bundling protein (By similarity) (498 aa)
            score_image   0.473
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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