node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMC4 | ZDHHC2 | ENSP00000306410 | ENSP00000262096 | armadillo repeat containing 4 | zinc finger, DHHC-type containing 2; Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity) | 0.854 |
CKAP4 | ZDHHC2 | ENSP00000367265 | ENSP00000262096 | cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF | zinc finger, DHHC-type containing 2; Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity) | 0.876 |
CNOT7 | VPS37A | ENSP00000355279 | ENSP00000318629 | CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] | vacuolar protein sorting 37 homolog A (S. cerevisiae); Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation | 0.540 |
CNOT7 | ZDHHC2 | ENSP00000355279 | ENSP00000262096 | CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] | zinc finger, DHHC-type containing 2; Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity) | 0.514 |
DDX21 | PHB2 | ENSP00000346120 | ENSP00000441875 | DEAD (Asp-Glu-Ala-Asp) box helicase 21; Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription. Involved in rRNA processing | prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | 0.758 |
DDX21 | REM1 | ENSP00000346120 | ENSP00000201979 | DEAD (Asp-Glu-Ala-Asp) box helicase 21; Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription. Involved in rRNA processing | RAS (RAD and GEM)-like GTP-binding 1; Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling | 0.532 |
DDX21 | ZDHHC2 | ENSP00000346120 | ENSP00000262096 | DEAD (Asp-Glu-Ala-Asp) box helicase 21; Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription. Involved in rRNA processing | zinc finger, DHHC-type containing 2; Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity) | 0.459 |
GOLGA7 | ZDHHC2 | ENSP00000350378 | ENSP00000262096 | golgin A7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS | zinc finger, DHHC-type containing 2; Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity) | 0.472 |
MTMR7 | VPS37A | ENSP00000180173 | ENSP00000318629 | myotubularin related protein 7; Phosphatase that acts on lipids with a phosphoinositol headgroup (Probable) | vacuolar protein sorting 37 homolog A (S. cerevisiae); Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation | 0.535 |
MTMR7 | ZDHHC2 | ENSP00000180173 | ENSP00000262096 | myotubularin related protein 7; Phosphatase that acts on lipids with a phosphoinositol headgroup (Probable) | zinc finger, DHHC-type containing 2; Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity) | 0.507 |
PHB2 | DDX21 | ENSP00000441875 | ENSP00000346120 | prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | DEAD (Asp-Glu-Ala-Asp) box helicase 21; Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription. Involved in rRNA processing | 0.758 |
PHB2 | REM1 | ENSP00000441875 | ENSP00000201979 | prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | RAS (RAD and GEM)-like GTP-binding 1; Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling | 0.667 |
PHB2 | ZDHHC2 | ENSP00000441875 | ENSP00000262096 | prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | zinc finger, DHHC-type containing 2; Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity) | 0.581 |
REM1 | DDX21 | ENSP00000201979 | ENSP00000346120 | RAS (RAD and GEM)-like GTP-binding 1; Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling | DEAD (Asp-Glu-Ala-Asp) box helicase 21; Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription. Involved in rRNA processing | 0.532 |
REM1 | PHB2 | ENSP00000201979 | ENSP00000441875 | RAS (RAD and GEM)-like GTP-binding 1; Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling | prohibitin 2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging | 0.667 |
REM1 | ZDHHC2 | ENSP00000201979 | ENSP00000262096 | RAS (RAD and GEM)-like GTP-binding 1; Promotes endothelial cell sprouting and actin cytoskeletal reorganization. May be involved in angiogenesis. May function in Ca(2+) signaling | zinc finger, DHHC-type containing 2; Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity) | 0.453 |
RTDR1 | ZDHHC2 | ENSP00000216036 | ENSP00000262096 | rhabdoid tumor deletion region gene 1 | zinc finger, DHHC-type containing 2; Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity) | 0.820 |
VPS37A | CNOT7 | ENSP00000318629 | ENSP00000355279 | vacuolar protein sorting 37 homolog A (S. cerevisiae); Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation | CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...] | 0.540 |
VPS37A | MTMR7 | ENSP00000318629 | ENSP00000180173 | vacuolar protein sorting 37 homolog A (S. cerevisiae); Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation | myotubularin related protein 7; Phosphatase that acts on lipids with a phosphoinositol headgroup (Probable) | 0.535 |
VPS37A | ZDHHC2 | ENSP00000318629 | ENSP00000262096 | vacuolar protein sorting 37 homolog A (S. cerevisiae); Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation | zinc finger, DHHC-type containing 2; Palmitoyltransferase specific for GAP43 and DLG4/PSD95 (By similarity) | 0.660 |