Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | EFCAB1 | EF-hand calcium binding domain 1 (211 aa) | ||||||||||||
Predicted Functional Partners:
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 | PI4KB | phosphatidylinositol 4-kinase, catalytic, beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (828 aa) |
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0.864 | |||||||||
 | METTL6 | methyltransferase like 6; Probable methyltransferase (By similarity) (284 aa) |
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0.761 | ||||||||||
 | PLEKHA8 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8; Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for [...] (519 aa) |
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0.707 | ||||||||||
 | KCTD1 | potassium channel tetramerisation domain containing 1; May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent (865 aa) |
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0.641 | ||||||||||
 | CRHR2 | corticotropin releasing hormone receptor 2; This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (438 aa) |
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0.613 | ||||||||||
 | CRHR1 | corticotropin releasing hormone receptor 1; Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (444 aa) |
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0.571 | ||||||||||
 | PLEKHA3 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3; Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P) (300 aa) |
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0.551 | ||||||||||
 | POTEE | POTE ankyrin domain family member E (1075 aa) |
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0.541 | |||||||||
 | POTEI | POTE ankyrin domain family, member I (1075 aa) |
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0.541 | |||||||||
 | POTEJ | POTE ankyrin domain family, member J (1038 aa) |
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0.541 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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