node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP1 | BMP2 | ENSP00000305714 | ENSP00000368104 | bone morphogenetic protein 1 | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.879 |
BMP1 | BMP4 | ENSP00000305714 | ENSP00000245451 | bone morphogenetic protein 1 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.880 |
BMP1 | CHRD | ENSP00000305714 | ENSP00000204604 | bone morphogenetic protein 1 | chordin | 0.996 |
BMP1 | CHRDL2 | ENSP00000305714 | ENSP00000263671 | bone morphogenetic protein 1 | chordin-like 2; May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation | 0.406 |
BMP1 | TWSG1 | ENSP00000305714 | ENSP00000262120 | bone morphogenetic protein 1 | twisted gastrulation homolog 1 (Drosophila); May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity) | 0.802 |
BMP2 | BMP1 | ENSP00000368104 | ENSP00000305714 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 1 | 0.879 |
BMP2 | BMP4 | ENSP00000368104 | ENSP00000245451 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.903 |
BMP2 | CHRD | ENSP00000368104 | ENSP00000204604 | bone morphogenetic protein 2; Induces cartilage and bone formation | chordin | 0.999 |
BMP2 | CHRDL1 | ENSP00000368104 | ENSP00000361112 | bone morphogenetic protein 2; Induces cartilage and bone formation | chordin-like 1; Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment e [...] | 0.913 |
BMP2 | CHRDL2 | ENSP00000368104 | ENSP00000263671 | bone morphogenetic protein 2; Induces cartilage and bone formation | chordin-like 2; May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation | 0.939 |
BMP2 | TWSG1 | ENSP00000368104 | ENSP00000262120 | bone morphogenetic protein 2; Induces cartilage and bone formation | twisted gastrulation homolog 1 (Drosophila); May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity) | 0.854 |
BMP2 | VWCE | ENSP00000368104 | ENSP00000334186 | bone morphogenetic protein 2; Induces cartilage and bone formation | von Willebrand factor C and EGF domains; May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma | 0.908 |
BMP4 | BMP1 | ENSP00000245451 | ENSP00000305714 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | bone morphogenetic protein 1 | 0.880 |
BMP4 | BMP2 | ENSP00000245451 | ENSP00000368104 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.903 |
BMP4 | CHRD | ENSP00000245451 | ENSP00000204604 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | chordin | 0.999 |
BMP4 | CHRDL1 | ENSP00000245451 | ENSP00000361112 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | chordin-like 1; Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment e [...] | 0.969 |
BMP4 | CHRDL2 | ENSP00000245451 | ENSP00000263671 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | chordin-like 2; May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation | 0.667 |
BMP4 | TWSG1 | ENSP00000245451 | ENSP00000262120 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | twisted gastrulation homolog 1 (Drosophila); May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity) | 0.939 |
CHRD | BMP1 | ENSP00000204604 | ENSP00000305714 | chordin | bone morphogenetic protein 1 | 0.996 |
CHRD | BMP2 | ENSP00000204604 | ENSP00000368104 | chordin | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.999 |