| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C8orf34 | MTFR1 | ENSP00000427820 | ENSP00000262146 | chromosome 8 open reading frame 34 | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | 0.470 |
| C8orf34 | NKAIN3 | ENSP00000427820 | ENSP00000333627 | chromosome 8 open reading frame 34 | Na+/K+ transporting ATPase interacting 3 | 0.655 |
| DICER1 | MTFR1 | ENSP00000343745 | ENSP00000262146 | dicer 1, ribonuclease type III; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre- miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering [...] | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | 0.481 |
| DNM1L | MTFR1 | ENSP00000450399 | ENSP00000262146 | dynamin 1-like | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | 0.504 |
| GTPBP1 | MTFR1 | ENSP00000216044 | ENSP00000262146 | GTP binding protein 1; Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity) | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | 0.661 |
| GTPBP1 | TFRC | ENSP00000216044 | ENSP00000353224 | GTP binding protein 1; Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity) | transferrin receptor (p90, CD71); Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin f [...] | 0.866 |
| MTFR1 | C8orf34 | ENSP00000262146 | ENSP00000427820 | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | chromosome 8 open reading frame 34 | 0.470 |
| MTFR1 | DICER1 | ENSP00000262146 | ENSP00000343745 | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | dicer 1, ribonuclease type III; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre- miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering [...] | 0.481 |
| MTFR1 | DNM1L | ENSP00000262146 | ENSP00000450399 | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | dynamin 1-like | 0.504 |
| MTFR1 | GTPBP1 | ENSP00000262146 | ENSP00000216044 | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | GTP binding protein 1; Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity) | 0.661 |
| MTFR1 | NKAIN3 | ENSP00000262146 | ENSP00000333627 | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | Na+/K+ transporting ATPase interacting 3 | 0.501 |
| MTFR1 | SETD6 | ENSP00000262146 | ENSP00000219315 | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | SET domain containing 6; Protein-lysine N-methyltransferase that specifically monomethylates ’Lys-310’ of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity | 0.582 |
| MTFR1 | STOML2 | ENSP00000262146 | ENSP00000348886 | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | stomatin (EPB72)-like 2; Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role [...] | 0.491 |
| MTFR1 | TFR2 | ENSP00000262146 | ENSP00000223051 | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | transferrin receptor 2; Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation | 0.426 |
| MTFR1 | TFRC | ENSP00000262146 | ENSP00000353224 | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | transferrin receptor (p90, CD71); Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin f [...] | 0.400 |
| NKAIN3 | C8orf34 | ENSP00000333627 | ENSP00000427820 | Na+/K+ transporting ATPase interacting 3 | chromosome 8 open reading frame 34 | 0.655 |
| NKAIN3 | MTFR1 | ENSP00000333627 | ENSP00000262146 | Na+/K+ transporting ATPase interacting 3 | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | 0.501 |
| SETD6 | MTFR1 | ENSP00000219315 | ENSP00000262146 | SET domain containing 6; Protein-lysine N-methyltransferase that specifically monomethylates ’Lys-310’ of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | 0.582 |
| STOML2 | MTFR1 | ENSP00000348886 | ENSP00000262146 | stomatin (EPB72)-like 2; Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role [...] | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | 0.491 |
| TFR2 | MTFR1 | ENSP00000223051 | ENSP00000262146 | transferrin receptor 2; Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | 0.426 |
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