Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | VIPR2 | vasoactive intestinal peptide receptor 2; This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C (438 aa) | ||||||||||||
Predicted Functional Partners:
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 | VIP | vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (170 aa) |
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0.998 | ||||||||
 | ADCYAP1 | adenylate cyclase activating polypeptide 1 (pituitary); Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (176 aa) |
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0.981 | ||||||||
 | NPS | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) (89 aa) |
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0.971 | |||||||||
 | GCG | glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life (180 aa) |
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0.964 | |||||||||
 | GHRH | growth hormone releasing hormone; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone (108 aa) |
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0.948 | |||||||||
 | PTH | parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells (115 aa) |
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0.938 | |||||||||
 | AVP | arginine vasopressin; Neurophysin 2 specifically binds vasopressin (164 aa) |
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0.933 | |||||||||
 | GIP | gastric inhibitory polypeptide; Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion (153 aa) |
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0.932 | |||||||||
 | CRH | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland (196 aa) |
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0.927 | |||||||||
 | POMC | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol (267 aa) |
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0.922 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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