node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNB1 | CCNB2 | ENSP00000256442 | ENSP00000288207 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.961 |
CCNB1 | CCNE1 | ENSP00000256442 | ENSP00000262643 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | 0.949 |
CCNB1 | CCNE2 | ENSP00000256442 | ENSP00000309181 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase | 0.496 |
CCNB1 | CDK1 | ENSP00000256442 | ENSP00000378699 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...] | 0.999 |
CCNB1 | CDK2 | ENSP00000256442 | ENSP00000266970 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...] | 0.999 |
CCNB1 | HSP90AA1 | ENSP00000256442 | ENSP00000335153 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.809 |
CCNB1 | HSP90AB1 | ENSP00000256442 | ENSP00000325875 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.743 |
CCNB1 | MYT1 | ENSP00000256442 | ENSP00000327465 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | myelin transcription factor 1; Binds to the promoter regions of proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendrogalia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription | 0.906 |
CCNB1 | PKMYT1 | ENSP00000256442 | ENSP00000262300 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | protein kinase, membrane associated tyrosine/threonine 1; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on ’Thr-14’. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on ’Tyr-15’ to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development | 0.998 |
CCNB1 | PLK1 | ENSP00000256442 | ENSP00000300093 | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...] | 0.999 |
CCNB2 | CCNB1 | ENSP00000288207 | ENSP00000256442 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.961 |
CCNB2 | CCNE1 | ENSP00000288207 | ENSP00000262643 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | 0.496 |
CCNB2 | CCNE2 | ENSP00000288207 | ENSP00000309181 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase | 0.495 |
CCNB2 | CDK1 | ENSP00000288207 | ENSP00000378699 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl- xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, G [...] | 0.999 |
CCNB2 | CDK2 | ENSP00000288207 | ENSP00000266970 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...] | 0.999 |
CCNB2 | HSP90AA1 | ENSP00000288207 | ENSP00000335153 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.725 |
CCNB2 | HSP90AB1 | ENSP00000288207 | ENSP00000325875 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.720 |
CCNB2 | PKMYT1 | ENSP00000288207 | ENSP00000262300 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | protein kinase, membrane associated tyrosine/threonine 1; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on ’Thr-14’. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on ’Tyr-15’ to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development | 0.987 |
CCNB2 | PLK1 | ENSP00000288207 | ENSP00000300093 | cyclin B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition | polo-like kinase 1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55 [...] | 0.998 |
CCNE1 | CCNB1 | ENSP00000262643 | ENSP00000256442 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | cyclin B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition | 0.949 |