| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DCXR | PARL | ENSP00000303356 | ENSP00000325421 | dicarbonyl/L-xylulose reductase; Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules | presenilin associated, rhomboid-like; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain | 0.611 |
| DCXR | RHBDF1 | ENSP00000303356 | ENSP00000262316 | dicarbonyl/L-xylulose reductase; Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules | rhomboid 5 homolog 1 (Drosophila); Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration | 0.861 |
| LUC7L | NPRL3 | ENSP00000293872 | ENSP00000382834 | LUC7-like (S. cerevisiae); May bind to RNA via its Arg/Ser-rich domain | nitrogen permease regulator-like 3 (S. cerevisiae) | 0.738 |
| LUC7L | POLR3K | ENSP00000293872 | ENSP00000293860 | LUC7-like (S. cerevisiae); May bind to RNA via its Arg/Ser-rich domain | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein [...] | 0.726 |
| LUC7L | RHBDF1 | ENSP00000293872 | ENSP00000262316 | LUC7-like (S. cerevisiae); May bind to RNA via its Arg/Ser-rich domain | rhomboid 5 homolog 1 (Drosophila); Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration | 0.637 |
| NME4 | NPRL3 | ENSP00000219479 | ENSP00000382834 | NME/NM23 nucleoside diphosphate kinase 4; Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity) | nitrogen permease regulator-like 3 (S. cerevisiae) | 0.553 |
| NME4 | POLR3K | ENSP00000219479 | ENSP00000293860 | NME/NM23 nucleoside diphosphate kinase 4; Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity) | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein [...] | 0.956 |
| NME4 | RAB11FIP3 | ENSP00000219479 | ENSP00000262305 | NME/NM23 nucleoside diphosphate kinase 4; Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity) | RAB11 family interacting protein 3 (class II) | 0.622 |
| NME4 | RHBDF1 | ENSP00000219479 | ENSP00000262316 | NME/NM23 nucleoside diphosphate kinase 4; Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity) | rhomboid 5 homolog 1 (Drosophila); Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration | 0.527 |
| NPRL3 | LUC7L | ENSP00000382834 | ENSP00000293872 | nitrogen permease regulator-like 3 (S. cerevisiae) | LUC7-like (S. cerevisiae); May bind to RNA via its Arg/Ser-rich domain | 0.738 |
| NPRL3 | NME4 | ENSP00000382834 | ENSP00000219479 | nitrogen permease regulator-like 3 (S. cerevisiae) | NME/NM23 nucleoside diphosphate kinase 4; Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity) | 0.553 |
| NPRL3 | POLR3K | ENSP00000382834 | ENSP00000293860 | nitrogen permease regulator-like 3 (S. cerevisiae) | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein [...] | 0.710 |
| NPRL3 | RAB11FIP3 | ENSP00000382834 | ENSP00000262305 | nitrogen permease regulator-like 3 (S. cerevisiae) | RAB11 family interacting protein 3 (class II) | 0.532 |
| NPRL3 | RHBDF1 | ENSP00000382834 | ENSP00000262316 | nitrogen permease regulator-like 3 (S. cerevisiae) | rhomboid 5 homolog 1 (Drosophila); Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration | 0.740 |
| PARL | DCXR | ENSP00000325421 | ENSP00000303356 | presenilin associated, rhomboid-like; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain | dicarbonyl/L-xylulose reductase; Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules | 0.611 |
| PARL | RHBDF1 | ENSP00000325421 | ENSP00000262316 | presenilin associated, rhomboid-like; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain | rhomboid 5 homolog 1 (Drosophila); Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration | 0.510 |
| PARL | RHBDL1 | ENSP00000325421 | ENSP00000219551 | presenilin associated, rhomboid-like; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptoptic signals (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain | rhomboid, veinlet-like 1 (Drosophila); May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors (By similarity) | 0.866 |
| POLR3K | LUC7L | ENSP00000293860 | ENSP00000293872 | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein [...] | LUC7-like (S. cerevisiae); May bind to RNA via its Arg/Ser-rich domain | 0.726 |
| POLR3K | NME4 | ENSP00000293860 | ENSP00000219479 | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein [...] | NME/NM23 nucleoside diphosphate kinase 4; Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity) | 0.956 |
| POLR3K | NPRL3 | ENSP00000293860 | ENSP00000382834 | polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein [...] | nitrogen permease regulator-like 3 (S. cerevisiae) | 0.710 |
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