node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY6 | ATP1B3 | ENSP00000311405 | ENSP00000286371 | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | ATPase, Na+/K+ transporting, beta 3 polypeptide; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known | 0.752 |
ADCY6 | PAIP2B | ENSP00000311405 | ENSP00000244221 | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | poly(A) binding protein interacting protein 2B | 0.753 |
ADCY6 | SLC1A1 | ENSP00000311405 | ENSP00000262352 | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | 0.688 |
ARL6IP5 | SLC1A1 | ENSP00000273258 | ENSP00000262352 | ADP-ribosylation-like factor 6 interacting protein 5; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic (By similarity) | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | 0.983 |
ATP1B3 | ADCY6 | ENSP00000286371 | ENSP00000311405 | ATPase, Na+/K+ transporting, beta 3 polypeptide; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | 0.752 |
ATP1B3 | PAIP2B | ENSP00000286371 | ENSP00000244221 | ATPase, Na+/K+ transporting, beta 3 polypeptide; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known | poly(A) binding protein interacting protein 2B | 0.800 |
ATP1B3 | SLC1A1 | ENSP00000286371 | ENSP00000262352 | ATPase, Na+/K+ transporting, beta 3 polypeptide; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | 0.750 |
GLIS3 | SLC1A1 | ENSP00000371398 | ENSP00000262352 | GLIS family zinc finger 3; Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5’-GACCACCCAC-3’ (By similarity) | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | 0.655 |
GLUL | SLC1A1 | ENSP00000307900 | ENSP00000262352 | glutamate-ammonia ligase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | 0.674 |
NFE2L2 | SLC1A1 | ENSP00000380252 | ENSP00000262352 | nuclear factor (erythroid-derived 2)-like 2; Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | 0.820 |
PAIP2B | ADCY6 | ENSP00000244221 | ENSP00000311405 | poly(A) binding protein interacting protein 2B | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | 0.753 |
PAIP2B | ATP1B3 | ENSP00000244221 | ENSP00000286371 | poly(A) binding protein interacting protein 2B | ATPase, Na+/K+ transporting, beta 3 polypeptide; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known | 0.800 |
PAIP2B | SLC1A1 | ENSP00000244221 | ENSP00000262352 | poly(A) binding protein interacting protein 2B | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | 0.751 |
RFX1 | SLC1A1 | ENSP00000254325 | ENSP00000262352 | regulatory factor X, 1 (influences HLA class II expression); Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes. Also binds to an inverted repeat (ENH1) required for hepatitis B virus genes expression and to the most upstream element (alpha) of the RPL30 promoter | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | 0.899 |
RTN2 | SLC1A1 | ENSP00000245923 | ENSP00000262352 | reticulon 2 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | 0.788 |
SLC1A1 | ADCY6 | ENSP00000262352 | ENSP00000311405 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity) | 0.688 |
SLC1A1 | ARL6IP5 | ENSP00000262352 | ENSP00000273258 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | ADP-ribosylation-like factor 6 interacting protein 5; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate. May be involved in membrane traffic (By similarity) | 0.983 |
SLC1A1 | ATP1B3 | ENSP00000262352 | ENSP00000286371 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | ATPase, Na+/K+ transporting, beta 3 polypeptide; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known | 0.750 |
SLC1A1 | GLIS3 | ENSP00000262352 | ENSP00000371398 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | GLIS family zinc finger 3; Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5’-GACCACCCAC-3’ (By similarity) | 0.655 |
SLC1A1 | GLUL | ENSP00000262352 | ENSP00000307900 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) | glutamate-ammonia ligase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts | 0.674 |