| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AZI2 | N4BP1 | ENSP00000419371 | ENSP00000262384 | 5-azacytidine induced 2; Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFN-beta promoter activation via TICAM1 | NEDD4 binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH’s substrates and impairing ubiquitination of substrates (By similarity) | 0.456 |
| AZI2 | UBC | ENSP00000419371 | ENSP00000344818 | 5-azacytidine induced 2; Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFN-beta promoter activation via TICAM1 | ubiquitin C | 0.832 |
| CAPZA1 | HMG20A | ENSP00000263168 | ENSP00000336856 | capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | high mobility group 20A; Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase MLL and consequent increased methylation of histone H3 lysine 4 (By similarity) | 0.506 |
| CAPZA1 | N4BP1 | ENSP00000263168 | ENSP00000262384 | capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | NEDD4 binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH’s substrates and impairing ubiquitination of substrates (By similarity) | 0.503 |
| CAPZA1 | UBC | ENSP00000263168 | ENSP00000344818 | capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | ubiquitin C | 0.945 |
| HMG20A | CAPZA1 | ENSP00000336856 | ENSP00000263168 | high mobility group 20A; Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase MLL and consequent increased methylation of histone H3 lysine 4 (By similarity) | capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | 0.506 |
| HMG20A | N4BP1 | ENSP00000336856 | ENSP00000262384 | high mobility group 20A; Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase MLL and consequent increased methylation of histone H3 lysine 4 (By similarity) | NEDD4 binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH’s substrates and impairing ubiquitination of substrates (By similarity) | 0.513 |
| HMG20A | UBC | ENSP00000336856 | ENSP00000344818 | high mobility group 20A; Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase MLL and consequent increased methylation of histone H3 lysine 4 (By similarity) | ubiquitin C | 0.510 |
| ITCH | N4BP1 | ENSP00000363998 | ENSP00000262384 | itchy E3 ubiquitin protein ligase | NEDD4 binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH’s substrates and impairing ubiquitination of substrates (By similarity) | 0.782 |
| ITCH | NDFIP1 | ENSP00000363998 | ENSP00000253814 | itchy E3 ubiquitin protein ligase | Nedd4 family interacting protein 1; Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through mult [...] | 0.816 |
| ITCH | NDFIP2 | ENSP00000363998 | ENSP00000218652 | itchy E3 ubiquitin protein ligase | Nedd4 family interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling | 0.930 |
| ITCH | UBC | ENSP00000363998 | ENSP00000344818 | itchy E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
| ITFG1 | LONP2 | ENSP00000319918 | ENSP00000285737 | integrin alpha FG-GAP repeat containing 1; Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity) | lon peptidase 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1 | 0.620 |
| ITFG1 | N4BP1 | ENSP00000319918 | ENSP00000262384 | integrin alpha FG-GAP repeat containing 1; Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity) | NEDD4 binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH’s substrates and impairing ubiquitination of substrates (By similarity) | 0.521 |
| ITFG1 | UBC | ENSP00000319918 | ENSP00000344818 | integrin alpha FG-GAP repeat containing 1; Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity) | ubiquitin C | 0.483 |
| LONP2 | ITFG1 | ENSP00000285737 | ENSP00000319918 | lon peptidase 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1 | integrin alpha FG-GAP repeat containing 1; Modulator of T-cell function. Has a protective effect in graft versus host disease model (By similarity) | 0.620 |
| LONP2 | N4BP1 | ENSP00000285737 | ENSP00000262384 | lon peptidase 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1 | NEDD4 binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH’s substrates and impairing ubiquitination of substrates (By similarity) | 0.607 |
| LONP2 | UBC | ENSP00000285737 | ENSP00000344818 | lon peptidase 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1 | ubiquitin C | 0.422 |
| N4BP1 | AZI2 | ENSP00000262384 | ENSP00000419371 | NEDD4 binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH’s substrates and impairing ubiquitination of substrates (By similarity) | 5-azacytidine induced 2; Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFN-beta promoter activation via TICAM1 | 0.456 |
| N4BP1 | CAPZA1 | ENSP00000262384 | ENSP00000263168 | NEDD4 binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH’s substrates and impairing ubiquitination of substrates (By similarity) | capping protein (actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments | 0.503 |
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