node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BUD31 | CDC40 | ENSP00000222969 | ENSP00000304370 | BUD31 homolog (S. cerevisiae) | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | 0.959 |
BUD31 | CRNKL1 | ENSP00000222969 | ENSP00000366557 | BUD31 homolog (S. cerevisiae) | crooked neck pre-mRNA splicing factor-like 1 (Drosophila) | 0.970 |
BUD31 | DHX8 | ENSP00000222969 | ENSP00000262415 | BUD31 homolog (S. cerevisiae) | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | 0.964 |
BUD31 | ISY1 | ENSP00000222969 | ENSP00000273541 | BUD31 homolog (S. cerevisiae) | ISY1 splicing factor homolog (S. cerevisiae); May play a role in pre-mRNA splicing (Potential) | 0.894 |
BUD31 | PRPF19 | ENSP00000222969 | ENSP00000227524 | BUD31 homolog (S. cerevisiae) | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] | 0.980 |
BUD31 | PRPF8 | ENSP00000222969 | ENSP00000304350 | BUD31 homolog (S. cerevisiae) | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.960 |
BUD31 | SLU7 | ENSP00000222969 | ENSP00000297151 | BUD31 homolog (S. cerevisiae) | SLU7 splicing factor homolog (S. cerevisiae); Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3’- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3’-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation | 0.830 |
BUD31 | SYF2 | ENSP00000222969 | ENSP00000236273 | BUD31 homolog (S. cerevisiae) | SYF2 homolog, RNA splicing factor (S. cerevisiae); May be involved in pre-mRNA splicing (By similarity) | 0.836 |
BUD31 | XAB2 | ENSP00000222969 | ENSP00000351137 | BUD31 homolog (S. cerevisiae) | XPA binding protein 2; Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing | 0.936 |
CDC40 | BUD31 | ENSP00000304370 | ENSP00000222969 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | BUD31 homolog (S. cerevisiae) | 0.959 |
CDC40 | CRNKL1 | ENSP00000304370 | ENSP00000366557 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | crooked neck pre-mRNA splicing factor-like 1 (Drosophila) | 0.984 |
CDC40 | DHX8 | ENSP00000304370 | ENSP00000262415 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | 0.989 |
CDC40 | ISY1 | ENSP00000304370 | ENSP00000273541 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | ISY1 splicing factor homolog (S. cerevisiae); May play a role in pre-mRNA splicing (Potential) | 0.831 |
CDC40 | PRPF18 | ENSP00000304370 | ENSP00000367835 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae); Participates in the second step of pre-mRNA splicing | 0.996 |
CDC40 | PRPF19 | ENSP00000304370 | ENSP00000227524 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] | 0.998 |
CDC40 | PRPF8 | ENSP00000304370 | ENSP00000304350 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.996 |
CDC40 | SLU7 | ENSP00000304370 | ENSP00000297151 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | SLU7 splicing factor homolog (S. cerevisiae); Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3’- splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3’-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation | 0.993 |
CDC40 | SYF2 | ENSP00000304370 | ENSP00000236273 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | SYF2 homolog, RNA splicing factor (S. cerevisiae); May be involved in pre-mRNA splicing (By similarity) | 0.982 |
CDC40 | XAB2 | ENSP00000304370 | ENSP00000351137 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | XPA binding protein 2; Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing | 0.983 |
CRNKL1 | BUD31 | ENSP00000366557 | ENSP00000222969 | crooked neck pre-mRNA splicing factor-like 1 (Drosophila) | BUD31 homolog (S. cerevisiae) | 0.970 |