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STRINGSTRING
MFAP4 MFAP4 ALOX5AP ALOX5AP CD2BP2 CD2BP2 ALOX5 ALOX5 COTL1 COTL1 ACTB ACTB PDE6H PDE6H UBC UBC ACTG1 ACTG1 ALOXE3 ALOXE3 ACTA1 ACTA1
"COTL1" - coactosin-like 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining
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co-expression
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protein homology
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COTL1coactosin-like 1 (Dictyostelium); Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis (142 aa)    
Predicted Functional Partners:
ALOX5
arachidonate 5-lipoxygenase; Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes (674 aa)
         score_image   score_image   0.977
ACTA1
actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (377 aa)
         score_image   score_image   0.813
UBC
ubiquitin C (685 aa)
         score_image       0.724
ALOX5AP
arachidonate 5-lipoxygenase-activating protein; Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (161 aa)
             score_image   0.661
CD2BP2
CD2 (cytoplasmic tail) binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly (341 aa)
         score_image       0.644
PDE6H
phosphodiesterase 6H, cGMP-specific, cone, gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones (83 aa)
         score_image       0.612
ACTB
actin, beta (375 aa)
         score_image   score_image   0.602
MFAP4
microfibrillar-associated protein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions (279 aa)
             score_image   0.589
ACTG1
actin, gamma 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (375 aa)
         score_image   score_image   0.577
ALOXE3
arachidonate lipoxygenase 3; Introduces molecular oxygen into polyunsaturated fatty acids. Exact substrate is not known (843 aa)
         score_image       0.569
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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