node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACSBG1 | SLC27A6 | ENSP00000258873 | ENSP00000262462 | acyl-CoA synthetase bubblegum family member 1; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids | solute carrier family 27 (fatty acid transporter), member 6; Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart | 0.817 |
ACSL1 | AGPAT6 | ENSP00000281455 | ENSP00000380184 | acyl-CoA synthetase long-chain family member 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs | 0.692 |
ACSL1 | CD36 | ENSP00000281455 | ENSP00000308165 | acyl-CoA synthetase long-chain family member 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate | CD36 molecule (thrombospondin receptor) | 0.471 |
ACSL1 | FABP3 | ENSP00000281455 | ENSP00000362817 | acyl-CoA synthetase long-chain family member 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor); FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters | 0.677 |
ACSL1 | LPIN1 | ENSP00000281455 | ENSP00000256720 | acyl-CoA synthetase long-chain family member 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate | lipin 1; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosp [...] | 0.734 |
ACSL1 | SLC27A6 | ENSP00000281455 | ENSP00000262462 | acyl-CoA synthetase long-chain family member 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate | solute carrier family 27 (fatty acid transporter), member 6; Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart | 0.851 |
ACSL5 | SLC27A6 | ENSP00000348429 | ENSP00000262462 | acyl-CoA synthetase long-chain family member 5; Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine [...] | solute carrier family 27 (fatty acid transporter), member 6; Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart | 0.732 |
AGPAT6 | ACSL1 | ENSP00000380184 | ENSP00000281455 | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs | acyl-CoA synthetase long-chain family member 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate | 0.692 |
AGPAT6 | FABP3 | ENSP00000380184 | ENSP00000362817 | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor); FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters | 0.625 |
AGPAT6 | INS | ENSP00000380184 | ENSP00000250971 | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.842 |
AGPAT6 | LPIN1 | ENSP00000380184 | ENSP00000256720 | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs | lipin 1; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosp [...] | 0.975 |
AGPAT6 | SLC27A6 | ENSP00000380184 | ENSP00000262462 | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs | solute carrier family 27 (fatty acid transporter), member 6; Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart | 0.761 |
CD36 | ACSL1 | ENSP00000308165 | ENSP00000281455 | CD36 molecule (thrombospondin receptor) | acyl-CoA synthetase long-chain family member 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate | 0.471 |
CD36 | FABP3 | ENSP00000308165 | ENSP00000362817 | CD36 molecule (thrombospondin receptor) | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor); FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters | 0.580 |
CD36 | INS | ENSP00000308165 | ENSP00000250971 | CD36 molecule (thrombospondin receptor) | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.941 |
CD36 | SLC27A6 | ENSP00000308165 | ENSP00000262462 | CD36 molecule (thrombospondin receptor) | solute carrier family 27 (fatty acid transporter), member 6; Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart | 0.722 |
FABP3 | ACSL1 | ENSP00000362817 | ENSP00000281455 | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor); FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters | acyl-CoA synthetase long-chain family member 1; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate | 0.677 |
FABP3 | AGPAT6 | ENSP00000362817 | ENSP00000380184 | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor); FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters | 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta); Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long- chain fatty acyl-CoAs | 0.625 |
FABP3 | CD36 | ENSP00000362817 | ENSP00000308165 | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor); FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters | CD36 molecule (thrombospondin receptor) | 0.580 |
FABP3 | INS | ENSP00000362817 | ENSP00000250971 | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor); FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.506 |