node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCY3 | GNAI1 | ENSP00000260600 | ENSP00000343027 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.938 |
ADCY3 | GNAO1 | ENSP00000260600 | ENSP00000262493 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | 0.961 |
ADCY3 | GNB1 | ENSP00000260600 | ENSP00000367869 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | guanine nucleotide binding protein (G protein), beta polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | 0.930 |
ADCY3 | MAPK3 | ENSP00000260600 | ENSP00000263025 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.559 |
ADCY3 | OPRM1 | ENSP00000260600 | ENSP00000394624 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | opioid receptor, mu 1 | 0.900 |
ADCY3 | PDE6G | ENSP00000260600 | ENSP00000328412 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | phosphodiesterase 6G, cGMP-specific, rod, gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones | 0.900 |
GNAI1 | ADCY3 | ENSP00000343027 | ENSP00000260600 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.938 |
GNAI1 | GNAO1 | ENSP00000343027 | ENSP00000262493 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | 0.955 |
GNAI1 | GNB1 | ENSP00000343027 | ENSP00000367869 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | guanine nucleotide binding protein (G protein), beta polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | 0.999 |
GNAI1 | MAPK1 | ENSP00000343027 | ENSP00000215832 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.963 |
GNAI1 | MAPK14 | ENSP00000343027 | ENSP00000229794 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.963 |
GNAI1 | MAPK3 | ENSP00000343027 | ENSP00000263025 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.968 |
GNAI1 | OPRM1 | ENSP00000343027 | ENSP00000394624 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | opioid receptor, mu 1 | 0.957 |
GNAI1 | PLCB2 | ENSP00000343027 | ENSP00000260402 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | phospholipase C, beta 2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.933 |
GNAI1 | RGS1 | ENSP00000343027 | ENSP00000356429 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | regulator of G-protein signaling 1; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation | 0.995 |
GNAO1 | ADCY3 | ENSP00000262493 | ENSP00000260600 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration | 0.961 |
GNAO1 | GNAI1 | ENSP00000262493 | ENSP00000343027 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.955 |
GNAO1 | GNB1 | ENSP00000262493 | ENSP00000367869 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | guanine nucleotide binding protein (G protein), beta polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | 0.992 |
GNAO1 | MAPK1 | ENSP00000262493 | ENSP00000215832 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] | 0.965 |
GNAO1 | MAPK14 | ENSP00000262493 | ENSP00000229794 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 | mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.962 |