node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMACR | HPN | ENSP00000371517 | ENSP00000262626 | alpha-methylacyl-CoA racemase | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | 0.649 |
F7 | HPN | ENSP00000364731 | ENSP00000262626 | coagulation factor VII (serum prothrombin conversion accelerator); Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | 0.665 |
HGF | HPN | ENSP00000222390 | ENSP00000262626 | hepatocyte growth factor (hepapoietin A; scatter factor) | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | 0.619 |
HGF | SPINT1 | ENSP00000222390 | ENSP00000342098 | hepatocyte growth factor (hepapoietin A; scatter factor) | serine peptidase inhibitor, Kunitz type 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) | 0.753 |
HPN | AMACR | ENSP00000262626 | ENSP00000371517 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | alpha-methylacyl-CoA racemase | 0.649 |
HPN | F7 | ENSP00000262626 | ENSP00000364731 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | coagulation factor VII (serum prothrombin conversion accelerator); Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium | 0.665 |
HPN | HGF | ENSP00000262626 | ENSP00000222390 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | hepatocyte growth factor (hepapoietin A; scatter factor) | 0.619 |
HPN | IGLL5 | ENSP00000262626 | ENSP00000431254 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | immunoglobulin lambda-like polypeptide 5 | 0.900 |
HPN | SLCO1A2 | ENSP00000262626 | ENSP00000305974 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin | 0.800 |
HPN | SLCO1C1 | ENSP00000262626 | ENSP00000370964 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | solute carrier organic anion transporter family, member 1C1; Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity) | 0.801 |
HPN | SLCO4A1 | ENSP00000262626 | ENSP00000217159 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | solute carrier organic anion transporter family, member 4A1; Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate | 0.800 |
HPN | SPINT1 | ENSP00000262626 | ENSP00000342098 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | serine peptidase inhibitor, Kunitz type 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) | 0.636 |
HPN | UBE2Q1 | ENSP00000262626 | ENSP00000292211 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | ubiquitin-conjugating enzyme E2Q family member 1 | 0.620 |
HPN | UBE2Q2 | ENSP00000262626 | ENSP00000267938 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | ubiquitin-conjugating enzyme E2Q family member 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 48’-linked polyubiquitination | 0.666 |
IGLL5 | HPN | ENSP00000431254 | ENSP00000262626 | immunoglobulin lambda-like polypeptide 5 | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | 0.900 |
SLCO1A2 | HPN | ENSP00000305974 | ENSP00000262626 | solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | 0.800 |
SLCO1C1 | HPN | ENSP00000370964 | ENSP00000262626 | solute carrier organic anion transporter family, member 1C1; Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity) | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | 0.801 |
SLCO4A1 | HPN | ENSP00000217159 | ENSP00000262626 | solute carrier organic anion transporter family, member 4A1; Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | 0.800 |
SPINT1 | HGF | ENSP00000342098 | ENSP00000222390 | serine peptidase inhibitor, Kunitz type 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) | hepatocyte growth factor (hepapoietin A; scatter factor) | 0.753 |
SPINT1 | HPN | ENSP00000342098 | ENSP00000262626 | serine peptidase inhibitor, Kunitz type 1; Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14) | hepsin; Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL | 0.636 |