CBFA2T2 protein (Homo sapiens) - STRING network view

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Score

CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2 (604 aa)

Predicted Functional Partners:

RUNX1

0.961

RUNX1T1

0.945

NCOR1

0.885

SIN3A

0.880

NEUROG2

0.808

NCOR2

0.791

MDFI

0.787

AKAP8

0.748

KAT6B

0.726

ACSM3

0.703

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSM3	CBFA2T2	ENSP00000289416	ENSP00000262653	acyl-CoA synthetase medium-chain family member 3; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity)	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	0.703
ACSM3	KAT6B	ENSP00000289416	ENSP00000287239	acyl-CoA synthetase medium-chain family member 3; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity)	K(lysine) acetyltransferase 6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity	0.739
AKAP8	CBFA2T2	ENSP00000269701	ENSP00000262653	A kinase (PRKA) anchor protein 8; Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II)	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	0.748
AKAP8	RUNX1T1	ENSP00000269701	ENSP00000402257	A kinase (PRKA) anchor protein 8; Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II)	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.483
CBFA2T2	ACSM3	ENSP00000262653	ENSP00000289416	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	acyl-CoA synthetase medium-chain family member 3; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity)	0.703
CBFA2T2	AKAP8	ENSP00000262653	ENSP00000269701	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	A kinase (PRKA) anchor protein 8; Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II)	0.748
CBFA2T2	KAT6B	ENSP00000262653	ENSP00000287239	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	K(lysine) acetyltransferase 6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity	0.726
CBFA2T2	MDFI	ENSP00000262653	ENSP00000230321	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	MyoD family inhibitor; Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the le [...]	0.787
CBFA2T2	NCOR1	ENSP00000262653	ENSP00000268712	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors	0.885
CBFA2T2	NCOR2	ENSP00000262653	ENSP00000384018	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	nuclear receptor corepressor 2; Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors	0.791
CBFA2T2	NEUROG2	ENSP00000262653	ENSP00000317333	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	neurogenin 2; Transcriptional regulator. Involved in neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’)	0.808
CBFA2T2	RUNX1	ENSP00000262653	ENSP00000300305	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	runt-related transcription factor 1	0.961
CBFA2T2	RUNX1T1	ENSP00000262653	ENSP00000402257	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.945
CBFA2T2	SIN3A	ENSP00000262653	ENSP00000353622	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	SIN3 transcription regulator homolog A (yeast); Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA (By similarity). Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation	0.880
KAT6B	ACSM3	ENSP00000287239	ENSP00000289416	K(lysine) acetyltransferase 6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity	acyl-CoA synthetase medium-chain family member 3; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity)	0.739
KAT6B	CBFA2T2	ENSP00000287239	ENSP00000262653	K(lysine) acetyltransferase 6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	0.726
KAT6B	RUNX1	ENSP00000287239	ENSP00000300305	K(lysine) acetyltransferase 6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity	runt-related transcription factor 1	0.936
MDFI	CBFA2T2	ENSP00000230321	ENSP00000262653	MyoD family inhibitor; Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the le [...]	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	0.787
NCOR1	CBFA2T2	ENSP00000268712	ENSP00000262653	nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors	core-binding factor, runt domain, alpha subunit 2; translocated to, 2	0.885
NCOR1	NCOR2	ENSP00000268712	ENSP00000384018	nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors	nuclear receptor corepressor 2; Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors	0.993

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