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SATL1 SATL1 DACH2 DACH2 XPNPEP2 XPNPEP2 NAP1L3 NAP1L3 DIAPH2 DIAPH2 POF1B POF1B TERF2IP TERF2IP FOXL2 FOXL2 FIGLA FIGLA NOBOX NOBOX NMT2 NMT2
"POF1B" - premature ovarian failure, 1B in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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Predicted Interactions
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POF1Bpremature ovarian failure, 1B; May be involved in ovary development (589 aa)    
Predicted Functional Partners:
FIGLA
folliculogenesis specific basic helix-loop-helix; Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian develop [...] (219 aa)
            score_image   0.748
DACH2
dachshund homolog 2 (Drosophila); Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by [...] (599 aa)
            score_image   0.734
DIAPH2
diaphanous homolog 2 (Drosophila); Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton (1101 aa)
            score_image   0.660
XPNPEP2
X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound; A metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. May also play a role in the metabolism of the vasodilator bradykinin (674 aa)
            score_image   0.610
NOBOX
NOBOX oogenesis homeobox; Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences 5’-TAATTG-3’, 5’-TAGTTG- 3’ and 5’-TAATTA-3’ (By similarity) (691 aa)
            score_image   0.610
FOXL2
forkhead box L2; Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-bi [...] (376 aa)
            score_image   0.561
NAP1L3
nucleosome assembly protein 1-like 3 (506 aa)
            score_image   0.514
SATL1
spermidine/spermine N1-acetyl transferase-like 1 (632 aa)
            score_image   0.472
TERF2IP
telomeric repeat binding factor 2, interacting protein; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR [...] (399 aa)
            score_image   0.455
NMT2
N-myristoyltransferase 2; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity) (498 aa)
            score_image   0.445
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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