node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COL4A6 | IGBP1 | ENSP00000361290 | ENSP00000348784 | collagen, type IV, alpha 6 | immunoglobulin (CD79A) binding protein 1; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits | 0.489 |
COL4A6 | MID2 | ENSP00000361290 | ENSP00000262843 | collagen, type IV, alpha 6 | midline 2 | 0.744 |
COL4A6 | PRPS1 | ENSP00000361290 | ENSP00000361512 | collagen, type IV, alpha 6 | phosphoribosyl pyrophosphate synthetase 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis | 0.561 |
COL4A6 | PRPS1L1 | ENSP00000361290 | ENSP00000424595 | collagen, type IV, alpha 6 | phosphoribosyl pyrophosphate synthetase 1-like 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis | 0.660 |
COL4A6 | PRPS2 | ENSP00000361290 | ENSP00000381504 | collagen, type IV, alpha 6 | phosphoribosyl pyrophosphate synthetase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis | 0.608 |
IGBP1 | COL4A6 | ENSP00000348784 | ENSP00000361290 | immunoglobulin (CD79A) binding protein 1; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits | collagen, type IV, alpha 6 | 0.489 |
IGBP1 | MID1 | ENSP00000348784 | ENSP00000312678 | immunoglobulin (CD79A) binding protein 1; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits | midline 1 (Opitz/BBB syndrome); Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination | 0.999 |
IGBP1 | MID2 | ENSP00000348784 | ENSP00000262843 | immunoglobulin (CD79A) binding protein 1; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits | midline 2 | 0.919 |
KIF1A | MID2 | ENSP00000322791 | ENSP00000262843 | kinesin family member 1A | midline 2 | 0.572 |
MID1 | IGBP1 | ENSP00000312678 | ENSP00000348784 | midline 1 (Opitz/BBB syndrome); Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination | immunoglobulin (CD79A) binding protein 1; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits | 0.999 |
MID1 | MID2 | ENSP00000312678 | ENSP00000262843 | midline 1 (Opitz/BBB syndrome); Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination | midline 2 | 0.972 |
MID1 | TRAT1 | ENSP00000312678 | ENSP00000295756 | midline 1 (Opitz/BBB syndrome); Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination | T cell receptor associated transmembrane adaptor 1; Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells | 0.585 |
MID2 | COL4A6 | ENSP00000262843 | ENSP00000361290 | midline 2 | collagen, type IV, alpha 6 | 0.744 |
MID2 | IGBP1 | ENSP00000262843 | ENSP00000348784 | midline 2 | immunoglobulin (CD79A) binding protein 1; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of PP2A, PP4 and PP6 phosphatases catalytic subunits by protecting them from degradative polyubiquitination until they associate with regulatory subunits | 0.919 |
MID2 | KIF1A | ENSP00000262843 | ENSP00000322791 | midline 2 | kinesin family member 1A | 0.572 |
MID2 | MID1 | ENSP00000262843 | ENSP00000312678 | midline 2 | midline 1 (Opitz/BBB syndrome); Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination | 0.972 |
MID2 | PRPS1 | ENSP00000262843 | ENSP00000361512 | midline 2 | phosphoribosyl pyrophosphate synthetase 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis | 0.659 |
MID2 | PRPS1L1 | ENSP00000262843 | ENSP00000424595 | midline 2 | phosphoribosyl pyrophosphate synthetase 1-like 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis | 0.746 |
MID2 | PRPS2 | ENSP00000262843 | ENSP00000381504 | midline 2 | phosphoribosyl pyrophosphate synthetase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis | 0.685 |
MID2 | SURF6 | ENSP00000262843 | ENSP00000361092 | midline 2 | surfeit 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly (By similarity) | 0.758 |