AMMECR1 protein (Homo sapiens) - STRING network view

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AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 (333 aa)

Predicted Functional Partners:

ACSL4

0.889

KCNE1L

0.813

COL4A5

0.760

MEMO1

0.736

GUCY2F

0.681

NXT2

0.662

MREG

0.607

GSK3B

0.566

CSNK1G1

0.566

AXIN2

0.566

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSL4	AMMECR1	ENSP00000339787	ENSP00000262844	acyl-CoA synthetase long-chain family member 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.889
ACSL4	COL4A5	ENSP00000339787	ENSP00000331902	acyl-CoA synthetase long-chain family member 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates	collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen	0.836
ACSL4	GUCY2F	ENSP00000339787	ENSP00000218006	acyl-CoA synthetase long-chain family member 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates	guanylate cyclase 2F, retinal; Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction	0.670
ACSL4	KCNE1L	ENSP00000339787	ENSP00000361173	acyl-CoA synthetase long-chain family member 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates	KCNE1-like	0.760
ACSL4	NXT2	ENSP00000339787	ENSP00000218004	acyl-CoA synthetase long-chain family member 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates	nuclear transport factor 2-like export factor 2	0.609
AMMECR1	ACSL4	ENSP00000262844	ENSP00000339787	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	acyl-CoA synthetase long-chain family member 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates	0.889
AMMECR1	AXIN2	ENSP00000262844	ENSP00000302625	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	axin 2; Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity)	0.566
AMMECR1	COL4A5	ENSP00000262844	ENSP00000331902	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen	0.760
AMMECR1	CSNK1G1	ENSP00000262844	ENSP00000305777	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	casein kinase 1, gamma 1; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN	0.566
AMMECR1	GSK3B	ENSP00000262844	ENSP00000324806	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	glycogen synthase kinase 3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...]	0.566
AMMECR1	GUCY2F	ENSP00000262844	ENSP00000218006	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	guanylate cyclase 2F, retinal; Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction	0.681
AMMECR1	KCNE1L	ENSP00000262844	ENSP00000361173	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	KCNE1-like	0.813
AMMECR1	MEMO1	ENSP00000262844	ENSP00000295065	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	mediator of cell motility 1; May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell mi [...]	0.736
AMMECR1	MREG	ENSP00000262844	ENSP00000263268	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	melanoregulin; Plays a role in the incorporation of pigments into hair. May function in membrane fusion and regulate the biogenesis of disk membranes of photoreceptor rod cells (By similarity)	0.607
AMMECR1	NXT2	ENSP00000262844	ENSP00000218004	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	nuclear transport factor 2-like export factor 2	0.662
AXIN2	AMMECR1	ENSP00000302625	ENSP00000262844	axin 2; Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity)	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.566
AXIN2	GSK3B	ENSP00000302625	ENSP00000324806	axin 2; Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity)	glycogen synthase kinase 3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...]	0.999
COL4A5	ACSL4	ENSP00000331902	ENSP00000339787	collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen	acyl-CoA synthetase long-chain family member 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates	0.836
COL4A5	AMMECR1	ENSP00000331902	ENSP00000262844	collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	0.760
COL4A5	GUCY2F	ENSP00000331902	ENSP00000218006	collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen	guanylate cyclase 2F, retinal; Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction	0.440

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