PRKX protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PRKX

protein kinase, X-linked; Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation (358 aa)

Predicted Functional Partners:

PRKAR1A

0.987

PRKAR2A

0.977

ADCY6

0.954

ADCY8

0.954

ADCY5

0.953

ADCY2

0.953

ADCY4

0.953

ADCY3

0.953

ADCY7

0.953

ADCY9

0.952

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY2	ADCY3	ENSP00000342952	ENSP00000260600	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	0.912
ADCY2	ADCY4	ENSP00000342952	ENSP00000312126	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 4; This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity)	0.903
ADCY2	ADCY5	ENSP00000342952	ENSP00000419361	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.964
ADCY2	ADCY6	ENSP00000342952	ENSP00000311405	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)	0.920
ADCY2	ADCY7	ENSP00000342952	ENSP00000254235	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.903
ADCY2	ADCY8	ENSP00000342952	ENSP00000286355	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 8 (brain); This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity)	0.917
ADCY2	ADCY9	ENSP00000342952	ENSP00000294016	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity)	0.931
ADCY2	PRKAR1A	ENSP00000342952	ENSP00000351410	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	protein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells	0.968
ADCY2	PRKAR2A	ENSP00000342952	ENSP00000265563	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase	0.968
ADCY2	PRKX	ENSP00000342952	ENSP00000262848	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	protein kinase, X-linked; Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation	0.953
ADCY3	ADCY2	ENSP00000260600	ENSP00000342952	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	0.912
ADCY3	ADCY4	ENSP00000260600	ENSP00000312126	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	adenylate cyclase 4; This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity)	0.926
ADCY3	ADCY5	ENSP00000260600	ENSP00000419361	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.911
ADCY3	ADCY6	ENSP00000260600	ENSP00000311405	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)	0.911
ADCY3	ADCY7	ENSP00000260600	ENSP00000254235	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.911
ADCY3	ADCY8	ENSP00000260600	ENSP00000286355	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	adenylate cyclase 8 (brain); This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity)	0.909
ADCY3	ADCY9	ENSP00000260600	ENSP00000294016	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity)	0.930
ADCY3	PRKAR1A	ENSP00000260600	ENSP00000351410	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	protein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells	0.968
ADCY3	PRKAR2A	ENSP00000260600	ENSP00000265563	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase	0.966
ADCY3	PRKX	ENSP00000260600	ENSP00000262848	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	protein kinase, X-linked; Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation	0.953

page 1 of 6

Experiments

Neighborhood

Databases

Fusion

Textmining

Cooccurrence

Coexpression

© STRING Consortium 2017

Credits

Access

Info

About