BPI protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Known Interactions

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Score

BPI

bactericidal/permeability-increasing protein (487 aa)

Predicted Functional Partners:

CEBPE

0.833

BPIFA2

0.700

PRTN3

0.700

CTSG

0.658

AMY1C

0.610

AMY1B

0.610

AMY1A

0.608

CAMP

0.587

BPIFA1

0.569

AZU1

0.562

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMY1A	BPI	ENSP00000359100	ENSP00000262865	amylase, alpha 1A (salivary)	bactericidal/permeability-increasing protein	0.608
AMY1B	BPI	ENSP00000330484	ENSP00000262865	amylase, alpha 1B (salivary)	bactericidal/permeability-increasing protein	0.610
AMY1C	BPI	ENSP00000359096	ENSP00000262865	amylase, alpha 1C (salivary)	bactericidal/permeability-increasing protein	0.610
AZU1	BPI	ENSP00000233997	ENSP00000262865	azurocidin 1; This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, thi [...]	bactericidal/permeability-increasing protein	0.562
AZU1	CAMP	ENSP00000233997	ENSP00000458149	azurocidin 1; This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, thi [...]	cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity	0.564
BPI	AMY1A	ENSP00000262865	ENSP00000359100	bactericidal/permeability-increasing protein	amylase, alpha 1A (salivary)	0.608
BPI	AMY1B	ENSP00000262865	ENSP00000330484	bactericidal/permeability-increasing protein	amylase, alpha 1B (salivary)	0.610
BPI	AMY1C	ENSP00000262865	ENSP00000359096	bactericidal/permeability-increasing protein	amylase, alpha 1C (salivary)	0.610
BPI	AZU1	ENSP00000262865	ENSP00000233997	bactericidal/permeability-increasing protein	azurocidin 1; This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, thi [...]	0.562
BPI	BPIFA1	ENSP00000262865	ENSP00000346251	bactericidal/permeability-increasing protein	BPI fold containing family A, member 1; May be involved in the airway inflammatory response after exposure to irritants. May be associated with tumor progression. May play a role in innate immune responses of the upper airways	0.569
BPI	BPIFA2	ENSP00000262865	ENSP00000253362	bactericidal/permeability-increasing protein	BPI fold containing family A, member 2	0.700
BPI	CAMP	ENSP00000262865	ENSP00000458149	bactericidal/permeability-increasing protein	cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity	0.587
BPI	CEBPE	ENSP00000262865	ENSP00000206513	bactericidal/permeability-increasing protein	CCAAT/enhancer binding protein (C/EBP), epsilon; C/EBP are DNA-binding proteins that recognize two different motifs- the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers	0.833
BPI	CTSG	ENSP00000262865	ENSP00000216336	bactericidal/permeability-increasing protein	cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride	0.658
BPI	PRTN3	ENSP00000262865	ENSP00000234347	bactericidal/permeability-increasing protein	proteinase 3	0.700
BPIFA1	BPI	ENSP00000346251	ENSP00000262865	BPI fold containing family A, member 1; May be involved in the airway inflammatory response after exposure to irritants. May be associated with tumor progression. May play a role in innate immune responses of the upper airways	bactericidal/permeability-increasing protein	0.569
BPIFA2	BPI	ENSP00000253362	ENSP00000262865	BPI fold containing family A, member 2	bactericidal/permeability-increasing protein	0.700
CAMP	AZU1	ENSP00000458149	ENSP00000233997	cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity	azurocidin 1; This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, thi [...]	0.564
CAMP	BPI	ENSP00000458149	ENSP00000262865	cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity	bactericidal/permeability-increasing protein	0.587
CAMP	CTSG	ENSP00000458149	ENSP00000216336	cathelicidin antimicrobial peptide; Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity	cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride	0.823

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