SLA2 protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Score

SLA2

Src-like-adaptor 2 (261 aa)

Predicted Functional Partners:

CBL

0.999

ZAP70

0.958

CD247

0.955

CD3D

0.912

CD3G

0.900

CD3E

0.900

HLA-DRB1

0.900

LCK

0.900

SLMAP

0.755

HIP1R

0.755

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CBL	CD247	ENSP00000264033	ENSP00000354782	Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...]	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	0.966
CBL	CD3D	ENSP00000264033	ENSP00000300692	Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...]	CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction	0.938
CBL	CD3E	ENSP00000264033	ENSP00000354566	Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...]	CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction	0.945
CBL	CD3G	ENSP00000264033	ENSP00000431445	Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...]	CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction	0.946
CBL	HLA-DRB1	ENSP00000264033	ENSP00000353099	Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...]	major histocompatibility complex, class II, DR beta 1	0.900
CBL	LCK	ENSP00000264033	ENSP00000337825	Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...]	lymphocyte-specific protein tyrosine kinase	0.999
CBL	SLA2	ENSP00000264033	ENSP00000262866	Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...]	Src-like-adaptor 2	0.999
CBL	ZAP70	ENSP00000264033	ENSP00000264972	Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...]	zeta-chain (TCR) associated protein kinase 70kDa; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization t [...]	0.999
CD247	CBL	ENSP00000354782	ENSP00000264033	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...]	0.966
CD247	CD3D	ENSP00000354782	ENSP00000300692	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction	0.985
CD247	CD3E	ENSP00000354782	ENSP00000354566	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction	0.995
CD247	CD3G	ENSP00000354782	ENSP00000431445	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction	0.972
CD247	HLA-DRB1	ENSP00000354782	ENSP00000353099	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	major histocompatibility complex, class II, DR beta 1	0.900
CD247	LCK	ENSP00000354782	ENSP00000337825	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	lymphocyte-specific protein tyrosine kinase	0.999
CD247	SLA2	ENSP00000354782	ENSP00000262866	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	Src-like-adaptor 2	0.955
CD247	ZAP70	ENSP00000354782	ENSP00000264972	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	zeta-chain (TCR) associated protein kinase 70kDa; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B-lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD247/CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization t [...]	0.999
CD3D	CBL	ENSP00000300692	ENSP00000264033	CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction	Cbl proto-oncogene, E3 ubiquitin protein ligase; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK and other kinases of the [...]	0.938
CD3D	CD247	ENSP00000300692	ENSP00000354782	CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction	CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering	0.985
CD3D	CD3E	ENSP00000300692	ENSP00000354566	CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction	CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction	0.999
CD3D	CD3G	ENSP00000300692	ENSP00000431445	CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction	CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction	0.965

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