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STRINGSTRING
PARG PARG PCNA PCNA OGG1 OGG1 PARP2 PARP2 PARP1 PARP1 XRCC1 XRCC1 POLB POLB LIG3 LIG3 APLF APLF APTX APTX PNKP PNKP
"XRCC1" - X-ray repair complementing defective repair in Chinese hamster cells 1 in Homo sapiens
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XRCC1X-ray repair complementing defective repair in Chinese hamster cells 1; Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents (633 aa)    
Predicted Functional Partners:
PARP1
poly (ADP-ribose) polymerase 1; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a [...] (1014 aa)
      score_image score_image   score_image   0.999
LIG3
ligase III, DNA, ATP-dependent; Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents (1009 aa)
        score_image score_image score_image   0.999
PNKP
polynucleotide kinase 3’-phosphatase; Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3’-phosphates from, or by phosphorylating 5’-hydroxyl groups on, the ribose sugar of the DNA backbone (521 aa)
        score_image   score_image   0.999
APTX
aprataxin (342 aa)
        score_image   score_image   0.999
POLB
polymerase (DNA directed), beta; Repair polymerase that plays a key role in base-excision repair. Has 5’-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5’ sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3’ end of the arising single-nucleotide gap. Conducts ’gap-filling’ DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases (335 aa)
        score_image score_image score_image   0.999
PARP2
poly (ADP-ribose) polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (583 aa)
        score_image   score_image   0.996
APLF
aprataxin and PNKP like factor; Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic- apyrimidinic (AP) endonuclease and 3’-5’ exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage (511 aa)
        score_image   score_image   0.994
OGG1
8-oxoguanine DNA glycosylase (424 aa)
        score_image   score_image   0.989
PCNA
proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] (261 aa)
      score_image score_image   score_image   0.988
PARG
poly (ADP-ribose) glycohydrolase (491 aa)
            score_image   0.976
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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