node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNA2 | CCNE1 | ENSP00000274026 | ENSP00000262643 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | 0.960 |
CCNA2 | CCNE2 | ENSP00000274026 | ENSP00000309181 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase | 0.618 |
CCNA2 | CDK2 | ENSP00000274026 | ENSP00000266970 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...] | 0.999 |
CCNA2 | CDK4 | ENSP00000274026 | ENSP00000257904 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] | 0.989 |
CCNA2 | E2F3 | ENSP00000274026 | ENSP00000262904 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | E2F transcription factor 3; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner | 0.997 |
CCNA2 | RB1 | ENSP00000274026 | ENSP00000267163 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | 0.999 |
CCNA2 | RBL1 | ENSP00000274026 | ENSP00000362768 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | retinoblastoma-like 1 (p107); Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 ’Lys-20’ trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with [...] | 0.995 |
CCNA2 | TFDP1 | ENSP00000274026 | ENSP00000364519 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | transcription factor Dp-1; Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5’-TTTC[CG]CGC-3’, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis | 0.960 |
CCNA2 | TFDP2 | ENSP00000274026 | ENSP00000420616 | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | transcription factor Dp-2 (E2F dimerization partner 2) | 0.949 |
CCNE1 | CCNA2 | ENSP00000262643 | ENSP00000274026 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | 0.960 |
CCNE1 | CCNE2 | ENSP00000262643 | ENSP00000309181 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase | 0.904 |
CCNE1 | CDK2 | ENSP00000262643 | ENSP00000266970 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and [...] | 0.999 |
CCNE1 | CDK4 | ENSP00000262643 | ENSP00000257904 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] | 0.995 |
CCNE1 | CREBBP | ENSP00000262643 | ENSP00000262367 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 | 0.683 |
CCNE1 | E2F3 | ENSP00000262643 | ENSP00000262904 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | E2F transcription factor 3; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner | 0.997 |
CCNE1 | RB1 | ENSP00000262643 | ENSP00000267163 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | retinoblastoma 1; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV [...] | 0.999 |
CCNE1 | RBL1 | ENSP00000262643 | ENSP00000362768 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | retinoblastoma-like 1 (p107); Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 ’Lys-20’ trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with [...] | 0.959 |
CCNE1 | TFDP1 | ENSP00000262643 | ENSP00000364519 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | transcription factor Dp-1; Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5’-TTTC[CG]CGC-3’, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis | 0.970 |
CCNE1 | TFDP2 | ENSP00000262643 | ENSP00000420616 | cyclin E1; Essential for the control of the cell cycle at the G1/S (start) transition | transcription factor Dp-2 (E2F dimerization partner 2) | 0.969 |
CCNE2 | CCNA2 | ENSP00000309181 | ENSP00000274026 | cyclin E2; Essential for the control of the cell cycle at the late G1 and early S phase | cyclin A2; Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions | 0.618 |