| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APOB | APOC2 | ENSP00000233242 | ENSP00000466775 | apolipoprotein B (including Ag(x) antigen) | apolipoprotein C-II; Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly | 0.920 |
| APOB | APOC3 | ENSP00000233242 | ENSP00000227667 | apolipoprotein B (including Ag(x) antigen) | apolipoprotein C-III; Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles | 0.987 |
| APOB | APOE | ENSP00000233242 | ENSP00000252486 | apolipoprotein B (including Ag(x) antigen) | apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues | 0.997 |
| APOB | C19orf10 | ENSP00000233242 | ENSP00000262947 | apolipoprotein B (including Ag(x) antigen) | chromosome 19 open reading frame 10 | 0.700 |
| APOB | GFPT1 | ENSP00000233242 | ENSP00000354347 | apolipoprotein B (including Ag(x) antigen) | glutamine--fructose-6-phosphate transaminase 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins | 0.644 |
| APOB | LPL | ENSP00000233242 | ENSP00000309757 | apolipoprotein B (including Ag(x) antigen) | lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity) | 0.997 |
| APOB | UBC | ENSP00000233242 | ENSP00000344818 | apolipoprotein B (including Ag(x) antigen) | ubiquitin C | 0.981 |
| APOC2 | APOB | ENSP00000466775 | ENSP00000233242 | apolipoprotein C-II; Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly | apolipoprotein B (including Ag(x) antigen) | 0.920 |
| APOC2 | APOC3 | ENSP00000466775 | ENSP00000227667 | apolipoprotein C-II; Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly | apolipoprotein C-III; Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles | 0.907 |
| APOC2 | APOE | ENSP00000466775 | ENSP00000252486 | apolipoprotein C-II; Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly | apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues | 0.983 |
| APOC2 | C19orf10 | ENSP00000466775 | ENSP00000262947 | apolipoprotein C-II; Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly | chromosome 19 open reading frame 10 | 0.480 |
| APOC2 | LPL | ENSP00000466775 | ENSP00000309757 | apolipoprotein C-II; Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly | lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity) | 0.979 |
| APOC3 | APOB | ENSP00000227667 | ENSP00000233242 | apolipoprotein C-III; Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles | apolipoprotein B (including Ag(x) antigen) | 0.987 |
| APOC3 | APOC2 | ENSP00000227667 | ENSP00000466775 | apolipoprotein C-III; Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles | apolipoprotein C-II; Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly | 0.907 |
| APOC3 | APOE | ENSP00000227667 | ENSP00000252486 | apolipoprotein C-III; Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles | apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues | 0.997 |
| APOC3 | C19orf10 | ENSP00000227667 | ENSP00000262947 | apolipoprotein C-III; Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles | chromosome 19 open reading frame 10 | 0.414 |
| APOC3 | LPL | ENSP00000227667 | ENSP00000309757 | apolipoprotein C-III; Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles | lipoprotein lipase; The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity) | 0.986 |
| APOE | APOB | ENSP00000252486 | ENSP00000233242 | apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues | apolipoprotein B (including Ag(x) antigen) | 0.997 |
| APOE | APOC2 | ENSP00000252486 | ENSP00000466775 | apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues | apolipoprotein C-II; Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly | 0.983 |
| APOE | APOC3 | ENSP00000252486 | ENSP00000227667 | apolipoprotein E; Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues | apolipoprotein C-III; Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles | 0.997 |
Share
