ZFR2 protein (Homo sapiens) - STRING network view

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Score

ZFR2

zinc finger RNA binding protein 2 (939 aa)

Predicted Functional Partners:

ILF2

0.792

HIPK3

0.690

ZFPL1

0.628

DHX9

0.624

DHX36

0.600

DHX30

0.600

DHX57

0.600

DHX29

0.600

HIPK2

0.596

HIPK1

0.596

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHX29	ZFR2	ENSP00000251636	ENSP00000262961	DEAH (Asp-Glu-Ala-His) box polypeptide 29; ATP-binding RNA helicase involved in translation initiation. Required for efficient initiation on mammalian mRNAs with structured 5’-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity	zinc finger RNA binding protein 2	0.600
DHX30	ZFR2	ENSP00000405620	ENSP00000262961	DEAH (Asp-Glu-Ala-His) box polypeptide 30; Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA	zinc finger RNA binding protein 2	0.600
DHX36	ZFR2	ENSP00000417078	ENSP00000262961	DEAH (Asp-Glu-Ala-His) box polypeptide 36; Plays a role in degradation and deadenylation of mRNAs containing in their 3’-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis	zinc finger RNA binding protein 2	0.600
DHX57	ZFR2	ENSP00000295373	ENSP00000262961	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57; Probable ATP-binding RNA helicase	zinc finger RNA binding protein 2	0.600
DHX9	ILF2	ENSP00000356520	ENSP00000355011	DEAH (Asp-Glu-Ala-His) box polypeptide 9; Unwinds double-stranded DNA and RNA in a 3’ to 5’ direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD- mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Positively regulates HIV-1 LTR-directed gene expression	interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus	0.919
DHX9	ZFR2	ENSP00000356520	ENSP00000262961	DEAH (Asp-Glu-Ala-His) box polypeptide 9; Unwinds double-stranded DNA and RNA in a 3’ to 5’ direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD- mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Positively regulates HIV-1 LTR-directed gene expression	zinc finger RNA binding protein 2	0.624
HIPK1	ZFR2	ENSP00000358571	ENSP00000262961	homeodomain interacting protein kinase 1	zinc finger RNA binding protein 2	0.596
HIPK2	ZFR2	ENSP00000385571	ENSP00000262961	homeodomain interacting protein kinase 2; Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect [...]	zinc finger RNA binding protein 2	0.596
HIPK3	ZFR2	ENSP00000304226	ENSP00000262961	homeodomain interacting protein kinase 3; Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation- phosphoryla [...]	zinc finger RNA binding protein 2	0.690
ILF2	DHX9	ENSP00000355011	ENSP00000356520	interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus	DEAH (Asp-Glu-Ala-His) box polypeptide 9; Unwinds double-stranded DNA and RNA in a 3’ to 5’ direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD- mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Positively regulates HIV-1 LTR-directed gene expression	0.919
ILF2	ZFR2	ENSP00000355011	ENSP00000262961	interleukin enhancer binding factor 2, 45kDa; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus	zinc finger RNA binding protein 2	0.792
ZFPL1	ZFR2	ENSP00000294258	ENSP00000262961	zinc finger protein-like 1; Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis-Golgi, possibly via its interaction with GOLGA2/GM130	zinc finger RNA binding protein 2	0.628
ZFR2	DHX29	ENSP00000262961	ENSP00000251636	zinc finger RNA binding protein 2	DEAH (Asp-Glu-Ala-His) box polypeptide 29; ATP-binding RNA helicase involved in translation initiation. Required for efficient initiation on mammalian mRNAs with structured 5’-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity	0.600
ZFR2	DHX30	ENSP00000262961	ENSP00000405620	zinc finger RNA binding protein 2	DEAH (Asp-Glu-Ala-His) box polypeptide 30; Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA	0.600
ZFR2	DHX36	ENSP00000262961	ENSP00000417078	zinc finger RNA binding protein 2	DEAH (Asp-Glu-Ala-His) box polypeptide 36; Plays a role in degradation and deadenylation of mRNAs containing in their 3’-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis	0.600
ZFR2	DHX57	ENSP00000262961	ENSP00000295373	zinc finger RNA binding protein 2	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57; Probable ATP-binding RNA helicase	0.600
ZFR2	DHX9	ENSP00000262961	ENSP00000356520	zinc finger RNA binding protein 2	DEAH (Asp-Glu-Ala-His) box polypeptide 9; Unwinds double-stranded DNA and RNA in a 3’ to 5’ direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD- mediated complex that promotes MYC mRNA stability. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Positively regulates HIV-1 LTR-directed gene expression	0.624
ZFR2	HIPK1	ENSP00000262961	ENSP00000358571	zinc finger RNA binding protein 2	homeodomain interacting protein kinase 1	0.596
ZFR2	HIPK2	ENSP00000262961	ENSP00000385571	zinc finger RNA binding protein 2	homeodomain interacting protein kinase 2; Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect [...]	0.596
ZFR2	HIPK3	ENSP00000262961	ENSP00000304226	zinc finger RNA binding protein 2	homeodomain interacting protein kinase 3; Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation- phosphoryla [...]	0.690

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