node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC94 | CDC40 | ENSP00000262962 | ENSP00000304370 | coiled-coil domain containing 94 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | 0.931 |
CCDC94 | CDC5L | ENSP00000262962 | ENSP00000360532 | coiled-coil domain containing 94 | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.978 |
CCDC94 | CRNKL1 | ENSP00000262962 | ENSP00000366557 | coiled-coil domain containing 94 | crooked neck pre-mRNA splicing factor-like 1 (Drosophila) | 0.901 |
CCDC94 | CWC22 | ENSP00000262962 | ENSP00000387006 | coiled-coil domain containing 94 | CWC22 spliceosome-associated protein homolog (S. cerevisiae); May be involved in pre-mRNA splicing | 0.876 |
CCDC94 | NCBP2 | ENSP00000262962 | ENSP00000326806 | coiled-coil domain containing 94 | nuclear cap binding protein subunit 2, 20kDa; Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5’ cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5’ end of mRNA and to mRNA export in a 5’ to 3’ direction through the nuclear pore. [...] | 0.872 |
CCDC94 | PLRG1 | ENSP00000262962 | ENSP00000424417 | coiled-coil domain containing 94 | pleiotropic regulator 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (By similarity) | 0.969 |
CCDC94 | PRPF19 | ENSP00000262962 | ENSP00000227524 | coiled-coil domain containing 94 | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] | 0.975 |
CCDC94 | SNRPA1 | ENSP00000262962 | ENSP00000254193 | coiled-coil domain containing 94 | small nuclear ribonucleoprotein polypeptide A’; This protein is associated with sn-RNP U2. It helps the A’ protein to bind stem loop IV of U2 snRNA | 0.894 |
CCDC94 | SNW1 | ENSP00000262962 | ENSP00000261531 | coiled-coil domain containing 94 | SNW domain containing 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators [...] | 0.879 |
CCDC94 | XAB2 | ENSP00000262962 | ENSP00000351137 | coiled-coil domain containing 94 | XPA binding protein 2; Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing | 0.954 |
CDC40 | CCDC94 | ENSP00000304370 | ENSP00000262962 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | coiled-coil domain containing 94 | 0.931 |
CDC40 | CDC5L | ENSP00000304370 | ENSP00000360532 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing | 0.983 |
CDC40 | CRNKL1 | ENSP00000304370 | ENSP00000366557 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | crooked neck pre-mRNA splicing factor-like 1 (Drosophila) | 0.984 |
CDC40 | CWC22 | ENSP00000304370 | ENSP00000387006 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | CWC22 spliceosome-associated protein homolog (S. cerevisiae); May be involved in pre-mRNA splicing | 0.952 |
CDC40 | NCBP2 | ENSP00000304370 | ENSP00000326806 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | nuclear cap binding protein subunit 2, 20kDa; Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5’ cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5’ end of mRNA and to mRNA export in a 5’ to 3’ direction through the nuclear pore. [...] | 0.990 |
CDC40 | PLRG1 | ENSP00000304370 | ENSP00000424417 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | pleiotropic regulator 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (By similarity) | 0.965 |
CDC40 | PRPF19 | ENSP00000304370 | ENSP00000227524 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...] | 0.998 |
CDC40 | SNRPA1 | ENSP00000304370 | ENSP00000254193 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | small nuclear ribonucleoprotein polypeptide A’; This protein is associated with sn-RNP U2. It helps the A’ protein to bind stem loop IV of U2 snRNA | 0.994 |
CDC40 | SNW1 | ENSP00000304370 | ENSP00000261531 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | SNW domain containing 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators [...] | 0.962 |
CDC40 | XAB2 | ENSP00000304370 | ENSP00000351137 | cell division cycle 40 homolog (S. cerevisiae); Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing | XPA binding protein 2; Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing | 0.983 |