node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRKL | EGFR | ENSP00000346300 | ENSP00000275493 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | epidermal growth factor receptor | 0.988 |
CRKL | FRS2 | ENSP00000346300 | ENSP00000299293 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | fibroblast growth factor receptor substrate 2; Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1 | 0.927 |
CRKL | GAB1 | ENSP00000346300 | ENSP00000262995 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | GRB2-associated binding protein 1; Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) | 0.999 |
CRKL | GRAP2 | ENSP00000346300 | ENSP00000339186 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | 0.958 |
CRKL | GRB2 | ENSP00000346300 | ENSP00000339007 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.965 |
CRKL | MET | ENSP00000346300 | ENSP00000317272 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | met proto-oncogene (hepatocyte growth factor receptor); Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1 [...] | 0.937 |
CRKL | PIK3R1 | ENSP00000346300 | ENSP00000274335 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.998 |
CRKL | PTPN11 | ENSP00000346300 | ENSP00000340944 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.987 |
CRKL | SHC1 | ENSP00000346300 | ENSP00000401303 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | SHC (Src homology 2 domain containing) transforming protein 1 | 0.894 |
CRKL | SOS1 | ENSP00000346300 | ENSP00000384675 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | son of sevenless homolog 1 (Drosophila); Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity) | 0.901 |
EGFR | CRKL | ENSP00000275493 | ENSP00000346300 | epidermal growth factor receptor | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | 0.988 |
EGFR | GAB1 | ENSP00000275493 | ENSP00000262995 | epidermal growth factor receptor | GRB2-associated binding protein 1; Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR) | 0.999 |
EGFR | GRAP2 | ENSP00000275493 | ENSP00000339186 | epidermal growth factor receptor | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | 0.903 |
EGFR | GRB2 | ENSP00000275493 | ENSP00000339007 | epidermal growth factor receptor | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.999 |
EGFR | MET | ENSP00000275493 | ENSP00000317272 | epidermal growth factor receptor | met proto-oncogene (hepatocyte growth factor receptor); Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1 [...] | 0.972 |
EGFR | PIK3R1 | ENSP00000275493 | ENSP00000274335 | epidermal growth factor receptor | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.999 |
EGFR | PTPN11 | ENSP00000275493 | ENSP00000340944 | epidermal growth factor receptor | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.999 |
EGFR | SHC1 | ENSP00000275493 | ENSP00000401303 | epidermal growth factor receptor | SHC (Src homology 2 domain containing) transforming protein 1 | 0.999 |
EGFR | SOS1 | ENSP00000275493 | ENSP00000384675 | epidermal growth factor receptor | son of sevenless homolog 1 (Drosophila); Promotes the exchange of Ras-bound GDP by GTP. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity (By similarity) | 0.999 |
FRS2 | CRKL | ENSP00000299293 | ENSP00000346300 | fibroblast growth factor receptor substrate 2; Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1 | v-crk sarcoma virus CT10 oncogene homolog (avian)-like; May mediate the transduction of intracellular signals | 0.927 |