| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACY3 | ADSS | ENSP00000255082 | ENSP00000355493 | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | adenylosuccinate synthase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP (By similarity) | 0.900 |
| ACY3 | ADSSL1 | ENSP00000255082 | ENSP00000333019 | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | adenylosuccinate synthase like 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity) | 0.900 |
| ACY3 | ASNS | ENSP00000255082 | ENSP00000175506 | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | asparagine synthetase (glutamine-hydrolyzing) | 0.900 |
| ACY3 | ASPA | ENSP00000255082 | ENSP00000263080 | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | 0.916 |
| ACY3 | ASS1 | ENSP00000255082 | ENSP00000253004 | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | 0.900 |
| ACY3 | CAD | ENSP00000255082 | ENSP00000264705 | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.902 |
| ACY3 | FOLH1 | ENSP00000255082 | ENSP00000256999 | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | folate hydrolase (prostate-specific membrane antigen) 1; Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity (By similarity) | 0.900 |
| ACY3 | GOT1 | ENSP00000255082 | ENSP00000359539 | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.900 |
| ACY3 | RIMKLA | ENSP00000255082 | ENSP00000414330 | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | ribosomal modification protein rimK-like family member A; Catalyzes the synthesis of N-acetylaspartyl-glutamate (NAAG) | 0.900 |
| ACY3 | RIMKLB | ENSP00000255082 | ENSP00000350136 | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | ribosomal modification protein rimK-like family member B; Catalyzes the synthesis of beta-citryl-glutamate and N- acetyl-aspartyl-glutamate. Beta-citryl-glutamate is synthesized more efficiently than N-acetyl-aspartyl-glutamate (By similarity) | 0.900 |
| ADSS | ACY3 | ENSP00000355493 | ENSP00000255082 | adenylosuccinate synthase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP (By similarity) | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | 0.900 |
| ADSS | ASNS | ENSP00000355493 | ENSP00000175506 | adenylosuccinate synthase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP (By similarity) | asparagine synthetase (glutamine-hydrolyzing) | 0.914 |
| ADSS | ASPA | ENSP00000355493 | ENSP00000263080 | adenylosuccinate synthase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP (By similarity) | aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | 0.900 |
| ADSS | ASS1 | ENSP00000355493 | ENSP00000253004 | adenylosuccinate synthase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP (By similarity) | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | 0.980 |
| ADSS | CAD | ENSP00000355493 | ENSP00000264705 | adenylosuccinate synthase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP (By similarity) | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.988 |
| ADSS | GOT1 | ENSP00000355493 | ENSP00000359539 | adenylosuccinate synthase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP (By similarity) | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...] | 0.902 |
| ADSSL1 | ACY3 | ENSP00000333019 | ENSP00000255082 | adenylosuccinate synthase like 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity) | aspartoacylase (aminocyclase) 3; Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity) | 0.900 |
| ADSSL1 | ASNS | ENSP00000333019 | ENSP00000175506 | adenylosuccinate synthase like 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity) | asparagine synthetase (glutamine-hydrolyzing) | 0.907 |
| ADSSL1 | ASPA | ENSP00000333019 | ENSP00000263080 | adenylosuccinate synthase like 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity) | aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids | 0.905 |
| ADSSL1 | ASS1 | ENSP00000333019 | ENSP00000253004 | adenylosuccinate synthase like 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity) | argininosuccinate synthase 1; Is indirectly involved in the control of blood pressure (By similarity) | 0.923 |
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