Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | WDR37 | WD repeat domain 37 (494 aa) | ||||||||||||
Predicted Functional Partners:
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 | PACS2 | phosphofurin acidic cluster sorting protein 2; Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct [...] (893 aa) |
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0.662 | ||||||||||
 | PACS1 | phosphofurin acidic cluster sorting protein 1 (963 aa) |
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0.662 | ||||||||||
 | BCAS3 | breast carcinoma amplified sequence 3 (928 aa) |
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0.549 | ||||||||||
 | CDKN2AIPNL | CDKN2A interacting protein N-terminal like (116 aa) |
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0.503 | ||||||||||
 | MCM3AP | minichromosome maintenance complex component 3 associated protein; May be involved in the nuclear localization pathway of MCM3 (1980 aa) |
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0.493 | ||||||||||
 | WDR88 | WD repeat domain 88 (472 aa) |
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0.479 | ||||||||||
 | TBL2 | transducin (beta)-like 2 (447 aa) |
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0.478 | ||||||||||
 | FBXW2 | F-box and WD repeat domain containing 2; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (454 aa) |
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0.466 | ||||||||||
 | WDR55 | WD repeat domain 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity) (383 aa) |
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0.454 | |||||||||
 | TMEM60 | transmembrane protein 60 (133 aa) |
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0.448 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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