| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1B10 | GABBR2 | ENSP00000352584 | ENSP00000259455 | aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | gamma-aminobutyric acid (GABA) B receptor, 2; Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a promi [...] | 0.610 |
| AKR1B10 | SLC17A6 | ENSP00000352584 | ENSP00000263160 | aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate | 0.659 |
| GABBR2 | AKR1B10 | ENSP00000259455 | ENSP00000352584 | gamma-aminobutyric acid (GABA) B receptor, 2; Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a promi [...] | aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | 0.610 |
| GABBR2 | SLC17A6 | ENSP00000259455 | ENSP00000263160 | gamma-aminobutyric acid (GABA) B receptor, 2; Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high- voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a promi [...] | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate | 0.609 |
| GAD1 | GAD2 | ENSP00000350928 | ENSP00000259271 | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | 0.919 |
| GAD1 | PVALB | ENSP00000350928 | ENSP00000216200 | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | parvalbumin; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions | 0.877 |
| GAD1 | SLC17A6 | ENSP00000350928 | ENSP00000263160 | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate | 0.795 |
| GAD1 | SLC18A3 | ENSP00000350928 | ENSP00000363229 | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | solute carrier family 18 (vesicular acetylcholine), member 3; Involved in acetylcholine transport into synaptic vesicles | 0.474 |
| GAD1 | SLC32A1 | ENSP00000350928 | ENSP00000217420 | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | solute carrier family 32 (GABA vesicular transporter), member 1; Involved in the uptake of GABA and glycine into the synaptic vesicles | 0.932 |
| GAD1 | SLC6A5 | ENSP00000350928 | ENSP00000434364 | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | solute carrier family 6 (neurotransmitter transporter, glycine), member 5; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses | 0.733 |
| GAD1 | TH | ENSP00000350928 | ENSP00000370571 | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | tyrosine hydroxylase; Plays an important role in the physiology of adrenergic neurons | 0.734 |
| GAD2 | GAD1 | ENSP00000259271 | ENSP00000350928 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA | 0.919 |
| GAD2 | PVALB | ENSP00000259271 | ENSP00000216200 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | parvalbumin; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions | 0.739 |
| GAD2 | SLC17A6 | ENSP00000259271 | ENSP00000263160 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate | 0.730 |
| GAD2 | SLC18A3 | ENSP00000259271 | ENSP00000363229 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | solute carrier family 18 (vesicular acetylcholine), member 3; Involved in acetylcholine transport into synaptic vesicles | 0.412 |
| GAD2 | SLC32A1 | ENSP00000259271 | ENSP00000217420 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | solute carrier family 32 (GABA vesicular transporter), member 1; Involved in the uptake of GABA and glycine into the synaptic vesicles | 0.965 |
| GAD2 | SLC6A5 | ENSP00000259271 | ENSP00000434364 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | solute carrier family 6 (neurotransmitter transporter, glycine), member 5; Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses | 0.674 |
| GAD2 | TH | ENSP00000259271 | ENSP00000370571 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA | tyrosine hydroxylase; Plays an important role in the physiology of adrenergic neurons | 0.631 |
| PHOX2B | SLC17A6 | ENSP00000226382 | ENSP00000263160 | paired-like homeobox 2b; Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum- response element | solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate | 0.609 |
| PHOX2B | TH | ENSP00000226382 | ENSP00000370571 | paired-like homeobox 2b; Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum- response element | tyrosine hydroxylase; Plays an important role in the physiology of adrenergic neurons | 0.665 |
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