PLEKHA4 protein (Homo sapiens) - STRING network view

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PLEKHA4

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides (779 aa)

Predicted Functional Partners:

BPIFC

0.693

PLEK

0.680

TMSB10

0.558

ADCY7

0.518

PSMD8

0.461

EPHX1

0.413

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY7	BPIFC	ENSP00000254235	ENSP00000300399	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	BPI fold containing family C	0.481
ADCY7	PLEKHA4	ENSP00000254235	ENSP00000263265	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides	0.518
BPIFC	ADCY7	ENSP00000300399	ENSP00000254235	BPI fold containing family C	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.481
BPIFC	PLEKHA4	ENSP00000300399	ENSP00000263265	BPI fold containing family C	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides	0.693
EPHX1	PLEKHA4	ENSP00000272167	ENSP00000263265	epoxide hydrolase 1, microsomal (xenobiotic)	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides	0.413
PLEK	PLEKHA4	ENSP00000234313	ENSP00000263265	pleckstrin; Major protein kinase C substrate of platelets	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides	0.680
PLEKHA4	ADCY7	ENSP00000263265	ENSP00000254235	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.518
PLEKHA4	BPIFC	ENSP00000263265	ENSP00000300399	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides	BPI fold containing family C	0.693
PLEKHA4	EPHX1	ENSP00000263265	ENSP00000272167	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides	epoxide hydrolase 1, microsomal (xenobiotic)	0.413
PLEKHA4	PLEK	ENSP00000263265	ENSP00000234313	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides	pleckstrin; Major protein kinase C substrate of platelets	0.680
PLEKHA4	PSMD8	ENSP00000263265	ENSP00000215071	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase	0.461
PLEKHA4	TMSB10	ENSP00000263265	ENSP00000233143	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides	thymosin beta 10; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity)	0.558
PSMD8	PLEKHA4	ENSP00000215071	ENSP00000263265	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides	0.461
PSMD8	TMSB10	ENSP00000215071	ENSP00000233143	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase	thymosin beta 10; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity)	0.486
TMSB10	PLEKHA4	ENSP00000233143	ENSP00000263265	thymosin beta 10; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity)	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides	0.558
TMSB10	PSMD8	ENSP00000233143	ENSP00000215071	thymosin beta 10; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity)	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Necessary for activation of the CDC28 kinase	0.486

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